Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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New Tools for Viscoelastic Spectral Analysis, with Application to the Mechanics of Cells and Collagen across Hierarchies
TL;DR: This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction.
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Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology
TL;DR: In this paper , the authors augment DNA velcro technology for selective patterning of single-stranded DNA (ssDNA)-labeled cells on mechanically defined photoactive polyacrylamide hydrogels.
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Spatial Distribution of Cytoskeletal Mechanical Properties in Vascular Smooth Muscle Cells
Qifeng Jiang,Ping Chen,Jinhe Li +2 more
TL;DR: Detailed intracellular maps of regional CSK stiffness and traction forces, as well as the structural rearrangement in vascular smooth muscle cells (VSMCs), provide the most detailed characterization to date concerning regional mechanical properties of the intact cytoskeleton.
Role of Mechanical Strain on the Cardiomyogenic Differentiation of Periodontal Ligament Derived Stem Cells
TL;DR: Cheung et al. as discussed by the authors used periodontal ligament-derived stem cells (PDLSC) to induce a cardiomyogenic response from the cells following just a couple of hours of stimulation.
Dissertation
Dynamique de la fermeture des trous épithéliaux en utilisant des techniques de micromécanique et de microfabrication
TL;DR: A novel approach to address epithelial gap closure under well-defined and controlled conditions is designed and it is observed that epithelial cells extend lamellipodia when exposed to a newly available space.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.