Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Mechanosensitive Expression of Lamellipodin Governs Cell Cycle Progression and Intracellular Stiffness
TL;DR: It is proposed that lamellipodin is a critical molecular lynchpin in the control of mechanosensitive cell cycle progression and intracellular stiffness.
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Comparative analysis of the residues of granular support bath materials on printed structures in embedded extrusion printing
Jinfeng Zeng,Zheng-Tian Xie,Fiona Louis,Yasumasa Dekishima,Setsuka Kuwagaki,Norihito Sakai,Michiya Matsusaki +6 more
TL;DR: In this article, the authors quantitatively compare the bath residues on fibrin gel fibers printed in granular gel baths that are conjugated with fluorescent probes for visualization, including physically crosslinked gellan gum (GG) and gelatin (GEL) baths and chemically crosslinked polyvinyl alcohol baths.
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A multiscale theory for spreading and migration of adhesion-reinforced mesenchymal cells
TL;DR: In this paper , a chemomechanical whole-cell theory for the spreading and migration dynamics of mesenchymal cells that can actively reinforce their adhesion to an underlying viscoelastic substrate as a function of its stiffness is presented.
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Mechanical mismatch between Ras transformed and untransformed epithelial cells.
TL;DR: It is found that adherent cells stiffen and suspended cells soften with the expression of constitutively active Ras, and the importance of the activation of ROCK by Ras and its effect on cell mechanics is established.
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Effect of therapeutic ultrasound on the mechanical and biological properties of fibroblasts
Rosy Paola Cardenas,Homero F. Pastrana-Rendón,Alba G. Ávila-Bernal,Angélica M. Ramírez-Martínez,Myriam Lucia Navarrete-Jiménez,Alejandro Ondo-Méndez,Diego Alexander Garzón-Alvarado +6 more
TL;DR: In this article, a multidisciplinary approach was used to apply ultrasound doses of 1.0 and 2.0 W/cm 2 at 1 MHz frequency for five days on ligament fibroblasts.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.