Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis.
Margaret A.T. Freeberg,Apostolos Perelas,Jane K. Rebman,Richard P. Phipps,Thomas H. Thatcher,Patricia J. Sime +5 more
TL;DR: Mechanosensors discussed here include integrins, piezo channels, transient receptor potential channels (TRP), and non-selective ion channels, and downstream transcription factors including MRTF and YAP/TAZ are discussed.
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Electrospun nanofibrils embedded hydrogel composites for cell cultivation in a biomimetic environment
TL;DR: NF/hydrogels are expected to serve as a cell culture matrix facilitating cell–matrix interactions by combining supportive nanofibrils and hydrogels in a cell-friendly environment mimicking the extracellular matrix.
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Shaping tissues by balancing active forces and geometric constraints
TL;DR: This topical review of how forces and geometry act together on scales from the single cell to tissues and organisms, and how their interaction determines biological shape and structure is summarized.
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Amphiphilic Block Copolymer Films: Phase Transition, Stabilization, and Nanoscale Templates
TL;DR: A morphological transition of asymmetric poly(styreneb-acrylic acid) (PS-b-PAA) films is observed by in situ scanning probe microscopy (SPM) in aqueous media.
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Nanoscale Surface Topography Reduces Focal Adhesions and Cell Stiffness by Enhancing Integrin Endocytosis.
Xiao Li,Lasse Hyldgaard Klausen,Wei Zhang,Zeinab Jahed,Ching-Ting Tsai,Thomas L. Li,Bianxiao Cui +6 more
TL;DR: In this paper, the authors demonstrate that the presence of nanotopography drastically alters cell behavior such that neurons and stem cells cultured on rigid glass substrates behave as if they were on soft hydrogels.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.