Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Whole tissue and single cell mechanics are correlated in human brain tumors.
Frank Sauer,Anatol Fritsch,Steffen Grosser,Steve Pawlizak,Tobias R Kießling,Martin Reiss-Zimmermann,Mehrgan Shahryari,Wolf Müller,Karl-Titus Hoffmann,Josef A. Käs,Ingolf Sack +10 more
TL;DR: In this paper, the relationship between the rheology of single cells measured ex-vivo and the living tumor was not yet understood, and the authors used a Kelvin-Voigt model to deduce two parameters related to cellular stiffness and cellular viscosity from magnetic resonance elastography (MRE) measurements in a time regimen that overlaps with that of MRE.
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Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis
Ai Kia Yip,Songjing Zhang,Lor Huai Chong,Elsie Cheruba,Jessie Yong Xing Woon,Theng Xuan Chua,Corinna Jie Hui Goh,Haibo Yang,Chor Yong Tay,Cheng-Gee Koh,Keng-Hwee Chiam +10 more
TL;DR: In this paper, the authors proposed zyxin as an essential protein that is required for rigidity sensing and durotaxis through modulating FA sizes, cell traction stress and F-actin organization.
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Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells.
TL;DR: The trabecular meshwork (TM) is composed of TM cells and beams of the extracellular matrix, together contributing to aqueous humor (AH) outflow resistance as discussed by the authors.
Characterization of the Interface between the Mouse Mammary Epithelium and its Microenvironment during Morphogenesis
TL;DR: Results demonstrate that extracellular stiffness is a critical cue of the cell-ECM interface that can regulate various processes in normal adult human mammary epithelial cells.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.