Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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A Tense Situation: Forcing Tumour Progression
TL;DR: The changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
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The physics of cancer: the role of physical interactions and mechanical forces in metastasis
TL;DR: The metastatic process is reconstructed and the importance of key physical and mechanical processes at each step of the cascade is described, which may help to solve some long-standing questions in disease progression and lead to new approaches to developing cancer diagnostics and therapies.
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The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.
Jennifer Park,Julia S. Chu,Anchi D. Tsou,Anchi D. Tsou,Rokhaya Diop,Rokhaya Diop,Zhenyu Tang,Zhenyu Tang,Aijun Wang,Song Li,Song Li +10 more
TL;DR: Insight is provided of how substrate stiffness differentially regulates stem cell differentiation, and have significant implications for the design of biomaterials with appropriate mechanical property for tissue regeneration.
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A Review of Cell Adhesion Studies for Biomedical and Biological Applications
TL;DR: The overview of the available methods to study cell adhesion through attachment and detachment events was discussed, which included the cell population and single cell approach.
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Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells
Farhan Chowdhury,Sungsoo Na,Sungsoo Na,Dong Li,Yeh Chuin Poh,Tetsuya S. Tanaka,Fei Wang,Ning Wang +7 more
TL;DR: It is shown that a local cyclic stress via focal adhesions induced spreading in mouse ES cells but not in mES cell-differentiated (ESD) cells that were 10-fold stiffer, demonstrating that cell softness dictates cellular sensitivity to force.
References
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Matrices with Compliance Comparable to that of Brain Tissue Select Neuronal over Glial Growth in Mixed Cortical Cultures
TL;DR: Data emphasize the potential importance of material substrate stiffness as a design feature in the next generation of biomaterials intended to promote neuronal regeneration across a lesion in the central nervous system while simultaneously minimizing the ingrowth of astrocytes into the lesion area.
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Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells
Ning Wang,Iva Marija Tolić-Norrelykke,Jianxin Chen,Srboljub M. Mijailovich,James P. Butler,Jeffrey J. Fredberg,Dimitrije Stamenović +6 more
TL;DR: Data establish a strong association between stiffness of HASM cells and the level of tensile stress within the cytoskeleton, a hallmark of systems that secure shape stability mainly through the prestress.
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Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion.
TL;DR: The mechanical properties of the underlying ECM regulate Rho‐mediated contractility in SMCs by disrupting a presumptive cell‐ECM force balance, which in turn regulates cytoskeletal assembly and ultimately, cell migration.
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Substrate flexibility regulates growth and apoptosis of normal but not transformed cells
TL;DR: It is demonstrated that responses to substrate rigidity play a major role in distinguishing the growth behavior of normal cells from that of transformed cells, and that proper mechanical feedback is required for regulating cell shape, cell growth, and survival.
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Measuring the Elastic Properties of Thin Polymer Films with the Atomic Force Microscope
Jan Domke,Manfred Radmacher +1 more
TL;DR: In this paper, the elastic properties of thin gelatin films were investigated with the atomic force microscope (AFM) with the major aim of this study was to investigate the influence of the film thickness on the apparent elastic (Young's) modulus.