Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Journal ArticleDOI
Measurement of the Bio-Mechanical Properties of Two Different Feeder Layer Cells
Sara Romanazzo,Sara Romanazzo,Kaoru Uesugi,Kaoru Uesugi,Akiyoshi Taniguchi,Giancarlo Forte,Keisuke Morishima,Keisuke Morishima +7 more
TL;DR: In this paper, the authors proposed a new method for biomedical engineering and applied it in the field of clinical research. But the method is not suitable for the medical field and it requires a large number of patients.
Dissertation
Dynamics of epithelial gap closure using microfabrication and micromechanical approaches
TL;DR: A novel approach to address epithelial gap closure under well-defined and controlled conditions is designed and it is observed that epithelial cells extend lamellipodia when exposed to a newly available space.
Dissertation
The Response of Cells to the Mechanical Environment: A Numerical Investigation of the Actin Cytoskeleton and Cell Adhesion
TL;DR: In this article, the authors present a survey of nomenclature and abbreviations for nouns and adjectives in the context of bioinformatics and bio-physics.
Journal ArticleDOI
Fluid–solid coupling dynamic model for oscillatory growth of multicellular lumens
TL;DR: In this paper , a fluid-solid coupling dynamic model is proposed to investigate the physical mechanisms underlying the oscillatory growth of lumens, and the overall change trend of the lumen volume is determined by the tissue development induced by cell proliferation and the fluid transport induced by the osmotic pressure.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.