Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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The promotion of neuronal maturation on soft substrates
Ana I. Teixeira,Shirin Ilkhanizadeh,Jens Wigenius,Joshua K. Duckworth,Olle Inganäs,Ola Hermanson +5 more
TL;DR: It is shown that soft substrates with elasticities commensurable to the elasticity of the brain promote the maturation of neural stem cell-derived neurons, defining a crucial parameter in neuronal differentiation of stem cells.
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Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells
Xiaoyue Ma,Maureen Erin Schickel,Mark D. Stevenson,Alisha L. Sarang-Sieminski,Keith J. Gooch,Samir N. Ghadiali,Richard T. Hart +6 more
TL;DR: The hypothesis that ECM fibers, especially aligned ones, play an important role in long-range stress transmission and provides an important mechanism for long- range cell-cell mechanical signaling is supported.
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Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells
TL;DR: Adhesive micropatterns show the effect of spatial confinement and actin network architecture on basal body positioning and primary cilium formation.
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Review on Cell Mechanics: Experimental and Modeling Approaches
TL;DR: A review of novel, experimental approaches and accompanying computational models to the use of microposts for experiments with cells and a bio-chemical-mechanical model for capturing their unique mechanobiological properties.
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Mechanical control of cardiac myofibroblasts.
TL;DR: This work discusses how mechanical factors, such as matrix stiffness and strain, are feeding back and cooperate with cytokine signals to drive myofibroblast activation and elaborate on the importance of considering the mechanical boundary conditions in the heart to generate better cell culture models for mechanistic studies of cardiac fibroblast function.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.