Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells
Young Mi Kim,Yun Gyeong Kang,So Hee Park,Myung-Kwan Han,Jae Ho Kim,Ji Won Shin,Jung-Woog Shin +6 more
TL;DR: This is the first study to show that mechanical stimuli can increase reprogramming efficiency, and mechanical stimuli, defined as stretching in this study, have positive effects on reprograming rather than on infection.
Journal ArticleDOI
The impact of environmental changes upon the microrheological response of adherent cells.
Cyril Picard,Athene M. Donald +1 more
TL;DR: The mechanical behaviour of adherent cells cultured in vitro is known to be dependent on the mechanical properties of the substrate, but it is shown that this mechanical behaviour is also strongly affected by the cells’ environment.
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Biophysical and morphological effects of nanodiamond/nanoplatinum solution (DPV576) on metastatic murine breast cancer cells in vitro.
Alia Ghoneum,Huanqi Zhu,JungReem Woo,Nikita Zabinyakov,Shivani Sharma,James K. Gimzewski,James K. Gimzewski +6 more
TL;DR: The changes in cell stiffness and tracks early structural alterations of metastatic breast cancer cells post treatment with DPV576 are demonstrated, which may have important implications in the role of nanodiamond/nanoplatinum based cancer cell therapy and sensitization to chemotherapy drugs.
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Cellular architecture and migration behavior of fibroblast cells on polyhydroxyoctanoate (PHO): A natural polymer of bacterial origin.
TL;DR: It is found that PHO exhibits no cellular cytotoxicity, similarly to a glass substrate, and a detailed analysis of actin and microtubule cytoskeletal architecture reveals changes in the density of actIn and micro Tubular networks.
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Shape regulation generates elastic interaction between living cells
Roman Golkov,Yair Shokef +1 more
TL;DR: In this paper, the authors model cells as spherical active force dipoles surrounded by an infinite elastic matrix, and analytically evaluate the interaction energy for different scenarios of their regulatory behavior.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.