Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
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Effect of Therapeutic Ultrasound on the Mechanical and Biological Properties of Fibroblasts
TL;DR: In this paper , the effect of pulsed ultrasound on the mechanical and biological properties of ligament fibroblasts was explored using a multidisciplinary approach, and it was shown that pulsed therapeutic ultrasound applied for 5 days reorganized the ligament fiber structure to increase the cell proliferation and migration at a low dose and to increase releasing proteins that give the stiffness of the healed ligament at a high dose.
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Mechanisms underlying divergent relationships between Ca <sup>2+</sup> and YAP/TAZ signalling
TL;DR: In this article , the authors developed a network model of Ca2+ -mediated YAP/TAZ signalling to investigate how temporal dynamics and crosstalk of signalling pathways interacting with Ca2+, as observed in experiments.
Posted ContentDOI
Biomechanical Dependence of SARS-CoV-2 Infections
Alexandra Paul,Sachin Kumar,Tamer S. Kaoud,Madison Pickett,Amanda L Bohanon,Janeta Zoldan,Kevin N. Dalby,Sapun H. Parekh +7 more
TL;DR: The results show that cells on softer and sparser scaffolds, closer resembling younger lungs, exhibit higher infection rates by the WT and D614G variant, suggesting that natural changes in lung biomechanics do not increase the propensity for SARS-CoV-2 infection and that other factors may contribute to increased disease burden in the elderly.
Mechanical Crosstalk Between Cell-Cell and Cell-Matrix Adhesions and Modulation of N-Cadherin-Mediated Proliferation by Cell Spreading
TL;DR: It is shown that matrix stiffness is the mechanistic basis for crosstalk between N-cadherin at cell-cell junctions and focal adhesion kinase (FAK) atcell-matrix adhesions, and that this interplay between adhesive systems modulates the proliferative role of N- cadher in.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.