Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Morphometry of cellular behavior of coelomocytes from starfish Asterias amurensis
Microtopographical control of cell adhesion, organization, and proliferation in a cardiac tissue engineering scaffold
TL;DR: In this article, the interaction between microtopographical cues and both fibroblasts and cardiomyocytes is further explored, showing that a fibroblast that is attached to a micropeg is less likely to proliferate than ones on a flat surface, but this difference can be partially abrogated in the presence of drugs that inhibit cell contractility.
Journal ArticleDOI
Elastic modulus of nanostructured polymer surfaces
Bin Tang,Bin Tang,Katerina E. Aifantis,Katerina E. Aifantis,Alfonso H.W. Ngan,Alfonso H.W. Ngan +5 more
TL;DR: In this paper, the modulus of nanostructured PDMS is doubled, while that of nano-scale ORMOCER increases by an order of magnitude, when compared to their flat counterparts.
Dissertation
The role of the mechanosensitive cation channel Piezo1 in the regulation of cardiac fibroblast function
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Role of galectin-3 in the elastic response of radial growth phase melanoma cancer cells.
Nataly Herrera-Reinoza,Tharcisio Citrangulo Tortelli Junior,Fernanda de Sá Teixeira,Roger Chammas,Maria Cecília Barbosa da Silveira Salvadori +4 more
TL;DR: In this paper , the elastic modulus of melanoma cells lacking galectin-3 was found to be significantly lower than those expressing Galectin3, and the gradient of the elasticity modulus in cells from the nuclear region towards the cell periphery was more pronounced in shGal3 cells.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.