Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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The effects of confluency on cell mechanical properties
Yu.M. Efremov,A. A. Dokrunova,Dmitry V. Bagrov,K.S. Kudryashova,Olga Sokolova,Konstantin V. Shaitan +5 more
TL;DR: The results show that intercellular contacts and cell motile state significantly influence the cell mechanical properties.
Journal ArticleDOI
Conductive elastomer composites for fully polymeric, flexible bioelectronics
Estelle A. Cuttaz,Estelle A. Cuttaz,Josef Goding,Catalina Vallejo-Giraldo,Ulises A. Aregueta-Robles,Nigel H. Lovell,Diego Ghezzi,Rylie A. Green +7 more
TL;DR: This work demonstrates the straightforward fabrication of fully organic electrode arrays based on conductive elastomers (CEs) as a soft, flexible and stretchable electroactive composite material.
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Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior.
Vijay Krishna Raghunathan,Julia S. Benoit,Ramesh B. Kasetti,Gulab Zode,Michelle Salemi,Brett S. Phinney,Kate E. Keller,Julia Staverosky,Christopher J. Murphy,Ted S. Acott,Janice A. Vranka +10 more
TL;DR: Data emanating from this study demonstrate that CDMs are a potent tool for the study of bidirectional interactions between TM cells and their immediate microenvironment, and changes in cell derived matrix (CDM) and tissue mechanics that contribute to the pathology.
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Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function.
Elie Simard,Thomas Söllradl,Jean-Sébastien Maltais,Julie Boucher,Pedro D'Orléans-Juste,Michel Grandbois +5 more
TL;DR: RAGE activation in VSMC could represent a keystone in the development of vascular diseases associated with diabetes by interfering with the contractile phenotype of VSMC through the modification of their mechanical and functional properties.
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Remodeling by fibroblasts alters the rate-dependent mechanical properties of collagen
Behzad Babaei,Ali Davarian,Sheng-Lin Lee,Kenneth M. Pryse,William B. McConnaughey,Elliot L. Elson,Guy M. Genin +6 more
TL;DR: The spectrum of viscoelastic (rate-dependent) changes arising from the remodeling of reconstituted collagen by fibroblasts is characterized for the first time, shedding light on hierarchical deformation mechanisms in tissues, and on pathologies related to collagen relaxation such as diastolic dysfunction.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.