Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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Rheology of Soft Materials
TL;DR: A review of the technical developments and current work in the field with partial aim to illustrate open questions for future research can be found in this article, along with a discussion of some open questions.
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Physics of adherent cells
TL;DR: Recent progress in the understanding of the role of forces in cell adhesion is reviewed from the viewpoint of theoretical soft matter physics and in close relation to the relevant experiments.
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Microfluidic tools for cell biological research
TL;DR: The basic concepts and methodologies in designing microfluidic devices, and their diverse cell biological applications, are reviewed.
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Cell volume change through water efflux impacts cell stiffness and stem cell fate.
Ming Guo,Adrian F. Pegoraro,Angelo S. Mao,Enhua H. Zhou,Praveen R. Arany,Yu Long Han,Yu Long Han,Dylan T. Burnette,Mikkel H. Jensen,Mikkel H. Jensen,Karen E. Kasza,Karen E. Kasza,Jeffrey R. Moore,Fred C. MacKintosh,Fred C. MacKintosh,Jeffrey J. Fredberg,David J. Mooney,Jennifer Lippincott-Schwartz,David A. Weitz +18 more
TL;DR: A robust and unified relationship between cell stiffness and cell volume is identified and it is found that changes in cell volume, and hence stiffness, alter stem-cell differentiation, regardless of the method by which these are induced.
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Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
Zhenjie Xu,Laura Schaedel,Didier Portran,Andrea Aguilar,Jérémie Gaillard,M. Peter Marinkovich,M. Peter Marinkovich,Manuel Théry,Manuel Théry,Maxence V. Nachury +9 more
TL;DR: It is found that tubulin acetylation is required for the mechanical stabilization of long-lived microtubules in cells and increases mechanical resilience to ensure the persistence ofLong-livedmicrotubules.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.