Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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A Tense Situation: Forcing Tumour Progression
TL;DR: The changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
Journal ArticleDOI
The physics of cancer: the role of physical interactions and mechanical forces in metastasis
TL;DR: The metastatic process is reconstructed and the importance of key physical and mechanical processes at each step of the cascade is described, which may help to solve some long-standing questions in disease progression and lead to new approaches to developing cancer diagnostics and therapies.
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The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.
Jennifer Park,Julia S. Chu,Anchi D. Tsou,Anchi D. Tsou,Rokhaya Diop,Rokhaya Diop,Zhenyu Tang,Zhenyu Tang,Aijun Wang,Song Li,Song Li +10 more
TL;DR: Insight is provided of how substrate stiffness differentially regulates stem cell differentiation, and have significant implications for the design of biomaterials with appropriate mechanical property for tissue regeneration.
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A Review of Cell Adhesion Studies for Biomedical and Biological Applications
TL;DR: The overview of the available methods to study cell adhesion through attachment and detachment events was discussed, which included the cell population and single cell approach.
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Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells
Farhan Chowdhury,Sungsoo Na,Sungsoo Na,Dong Li,Yeh Chuin Poh,Tetsuya S. Tanaka,Fei Wang,Ning Wang +7 more
TL;DR: It is shown that a local cyclic stress via focal adhesions induced spreading in mouse ES cells but not in mES cell-differentiated (ESD) cells that were 10-fold stiffer, demonstrating that cell softness dictates cellular sensitivity to force.
References
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Tensegrity and mechanoregulation: from skeleton to cytoskeleton
TL;DR: Fundamental design principles that are used to stabilize the musculoskeletal system at many different size scales are described and it is shown that these design features are embodied in one particular form of architecture that is known as tensegrity.
Book ChapterDOI
Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions.
TL;DR: A powerful tool for the study of mechanical interactions between cells and their physical environment, this method will be particularly useful for studying the functions of various components at focal adhesions, and the effects of mechanical forces on focal adhesion-mediated signal transduction.
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Mechanics of vimentin intermediate filaments.
Ning Wang,D. Stamenovic +1 more
TL;DR: Vimentin, a major structural component of IFs is many cell types, is shown to play an important role in vital mechanical and biological functions such as cell contractility, migration, stifness, stiffening, and proliferation.
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Crosslinked chitosan: its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferation
Anuradha Subramanian,Hsin-Yi Lin +1 more
TL;DR: The crosslinked chitosan was found to be nontoxic to chondrocytes and more hydrophilic and its compression modulus and stiffness increased, which may improve the scaffold resistance to wear and in vivo shrinkage once implanted.
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Strain hardening of fibrin gels and plasma clots
Jagesh V. Shah,Paul A. Janmey +1 more
TL;DR: In this article, the authors show that fibrin clots and plasma clots devoid of platelets exhibit shear moduli at strains of approximately 50% that are as much as 20 times the modulus at small strains.