Open Access
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque
Joshua C. Bis,Maryam Kavousi,Nora Franceschini,Aaron Isaacs,Gonçalo R. Abecasis,Ulf Schminke,Wendy S. Post,Albert V. Smith,L. Adrienne Cupples,Hugh S. Markus,Reinhold E. Schmidt,Jennifer E. Huffman,Terho Lehtimäki,Jens Baumert,Thomas Muenzel,Susan R. Heckbert,Abbas Dehghan,Kari E. North,Ben A. Oostra,Steve Bevan,Eva-Maria Stoegerer,Caroline Hayward,Olli T. Raitakari,Christa Meisinger,Arne Schillert,Serena Sanna,Henry Voelzke,Yu-Ching Cheng,Bolli Thorsson,Caroline S. Fox,Kenneth Rice,Fernando Rivadeneira,Vijay Nambi,Eran Halperin,K. Petrovic,Leena Peltonen,H.-Erich Wichmann,Renate B. Schnabel,Marcus Doerr,Afshin Parsa,Thor Aspelund,Serkalem Demissie,Sekar Kathiresan,Muredach P. Reilly,Kent D. Taylor,André G. Uitterlinden,David Couper,Matthias Sitzer,Mika Kähönen,Thomas Illig,Philipp S. Wild,Marco Orru,Jan Luedemann,Alan R. Shuldiner,Gudny Eiriksdottir,Charles C. White,Jerome I. Rotter,Albert Hofman,Jochen Seissler,Tanja Zeller,Gianluca Usala,Florian Ernst,Lenore J. Launer,Ralph B. D'Agostino,Daniel H. O'Leary,Christie M. Ballantyne,Joachim Thiery,Andreas Ziegler,Edward G. Lakatta,Ravi Kumar Chilukoti,Tamara B. Harris,Philip A. Wolf,Bruce M. Psaty,Joseph F. Polak,Xia Li,Wolfgang Rathmann,Manuela Uda,Eric Boerwinkle,Norman Klopp,Helena Schmidt,James F. Wilson,Jorma Viikari,Wolfgang Koenig,Stefan Blankenberg,Anne B. Newman,Jacqueline C.M. Witteman,Gerardo Heiss,Cornelia M. van Duijn,Angelo Scuteri,Georg Homuth,Braxton D. Mitchell,Vilmundur Gudnason,Christopher J. O'Donnell +92 more
Reads0
Chats0
About:
The article was published on 2011-01-01 and is currently open access. It has received 186 citations till now. The article focuses on the topics: Intima-media thickness.read more
Citations
More filters
Journal ArticleDOI
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas,Stavroula Kanoni,Christina Willenborg,Martin Farrall,Themistocles L. Assimes,John R. Thompson,Erik Ingelsson,Danish Saleheen,Danish Saleheen,Jeanette Erdmann,Benjamin A. Goldstein,Kathleen Stirrups,Inke R. König,Jean-Baptiste Cazier,Åsa Johansson,Alistair S. Hall,Jong-Young Lee,Cristen J. Willer,John C. Chambers,Tõnu Esko,Lasse Folkersen,Anuj Goel,Elin Grundberg,Aki S. Havulinna,Weang K. Ho,Jemma C. Hopewell,Niclas Eriksson,Marcus E. Kleber,Kati Kristiansson,Per Lundmark,Leo-Pekka Lyytikäinen,Suzanne Rafelt,Dmitry Shungin,Dmitry Shungin,Rona J. Strawbridge,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Natalie R. van Zuydam,Benjamin F. Voight,Lindsay L. Waite,Weihua Zhang,Andreas Ziegler,Devin Absher,David Altshuler,David Altshuler,Anthony J. Balmforth,Inês Barroso,Inês Barroso,Peter S. Braund,Peter S. Braund,Christof Burgdorf,Simone Claudi-Boehm,David G. Cox,Maria Dimitriou,Ron Do,Ron Do,Alex S. F. Doney,Nour Eddine El Mokhtari,Per Eriksson,Krista Fischer,Pierre Fontanillas,Anders Franco-Cereceda,Bruna Gigante,Leif Groop,Stefan Gustafsson,Jorg Hager,Göran Hallmans,Bok Ghee Han,Sarah E. Hunt,Hyun Min Kang,Thomas Illig,Thorsten Kessler,Joshua W. Knowles,Genovefa Kolovou,Johanna Kuusisto,Claudia Langenberg,Cordelia Langford,Karin Leander,Marja-Liisa Lokki,Anders Lundmark,Mark I. McCarthy,Christa Meisinger,Olle Melander,Evelin Mihailov,Seraya Maouche,Andrew D. Morris,Martina Müller-Nurasyid,Kjell Nikus,John F. Peden,N. William Rayner,Asif Rasheed,Silke Rosinger,Diana Rubin,Moritz P. Rumpf,Arne Schäfer,Mohan U. Sivananthan,Ci Song,Alexandre F.R. Stewart,Sian Tsung Tan,Gudmundur Thorgeirsson,C. Ellen van der Schoot,Peter Wagner,Peter Wagner,George A. Wells,Philipp S. Wild,Tsun-Po Yang,Philippe Amouyel,Dominique Arveiler,Hanneke Basart,Michael Boehnke,Eric Boerwinkle,Paolo Brambilla,François Cambien,Adrienne Cupples,Adrienne Cupples,Ulf de Faire,Abbas Dehghan,Patrick Diemert,Stephen E. Epstein,Alun Evans,Marco M Ferrario,Jean Ferrières,Dominique Gauguier,Dominique Gauguier,Alan S. Go,Alison H. Goodall,Alison H. Goodall,Villi Gudnason,Stanley L. Hazen,Hilma Holm,Carlos Iribarren,Yangsoo Jang,Mika Kähönen,Frank Kee,Hyo-Soo Kim,Norman Klopp,Wolfgang Koenig,Wolfgang Kratzer,Kari Kuulasmaa,Markku Laakso,Reijo Laaksonen,Jiyoung Lee,Lars Lind,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Sarah Parish,Jeong E. Park,Nancy L. Pedersen,Annette Peters,Thomas Quertermous,Daniel J. Rader,Veikko Salomaa,Eric E. Schadt,Svati H. Shah,Juha Sinisalo,Klaus Stark,Kari Stefansson,Kari Stefansson,David-Alexandre Trégouët,Jarmo Virtamo,Lars Wallentin,Nicholas J. Wareham,Martina E. Zimmermann,Markku S. Nieminen,Christian Hengstenberg,Manjinder S. Sandhu,Manjinder S. Sandhu,Tomi Pastinen,Ann-Christine Syvänen,G. Kees Hovingh,George Dedoussis,Paul W. Franks,Paul W. Franks,Paul W. Franks,Terho Lehtimäki,Andres Metspalu,Pierre Zalloua,Agneta Siegbahn,Stefan Schreiber,Samuli Ripatti,Samuli Ripatti,Stefan Blankenberg,Markus Perola,Robert Clarke,Bernhard O. Boehm,Christopher J. O'Donnell,Muredach P. Reilly,Winfried März,Winfried März,Rory Collins,Sekar Kathiresan,Sekar Kathiresan,Anders Hamsten,Jaspal S. Kooner,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,John Danesh,Colin N. A. Palmer,Robert Roberts,Hugh Watkins,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani +204 more
TL;DR: An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Journal ArticleDOI
The Rotterdam Study: Objectives and design update
Albert Hofman,Guy Brusselle,Sarwa Darwish Murad,Cornelia M. van Duijn,Oscar H. Franco,André Goedegebure,M. Arfan Ikram,Caroline C W Klaver,Tamar Nijsten,Robin P. Peeters,Bruno H. Ch. Stricker,Henning Tiemeier,André G. Uitterlinden,Meike W. Vernooij +13 more
TL;DR: The rationale of the study and its design is given, and a summary of the major findings and an update of the objectives and methods are presented.
Journal ArticleDOI
Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004-2006-2011). An Update on Behalf of the Advisory Board of the 3rd, 4th and 5th Watching the Risk Symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011.
Pierre-Jean Touboul,M.G. Hennerici,Stephen Meairs,Harold P. Adams,Pierre Amarenco,N. M. Bornstein,László Csiba,M. Desvarieux,Shah Ebrahim,R. Hernandez Hernandez,Michael R. Jaff,S. Kownator,Tasneem Z. Naqvi,Patrizio Prati,Tatjana Rundek,Matthias Sitzer,Ulf Schminke,J.-C. Tardif,A. Taylor,Eric Vicaut,K.S. Woo +20 more
TL;DR: This updated consensus document delineates further criteria to distinguish early atherosclerotic plaque formation from thickening of IMT and recommends against serial monitoring in individual patients.
Journal ArticleDOI
Rare and common variants: twenty arguments
TL;DR: 20 arguments for and against each of these models of the genetic basis of complex traits are reviewed and it is concluded that both classes of effect can be readily reconciled.
Journal ArticleDOI
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
TL;DR: A multiancestry genome-wide-association meta-analysis in 521,612 individuals and discovered 22 new stroke risk loci and eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
References
More filters
Journal ArticleDOI
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
Shaun Purcell,Shaun Purcell,Benjamin M. Neale,Benjamin M. Neale,Kathe Todd-Brown,Lori Thomas,Manuel A. R. Ferreira,David Bender,David Bender,Julian Maller,Julian Maller,Pamela Sklar,Pamela Sklar,Paul I.W. de Bakker,Paul I.W. de Bakker,Mark J. Daly,Mark J. Daly,Pak C. Sham +17 more
TL;DR: This work introduces PLINK, an open-source C/C++ WGAS tool set, and describes the five main domains of function: data management, summary statistics, population stratification, association analysis, and identity-by-descent estimation, which focuses on the estimation and use of identity- by-state and identity/descent information in the context of population-based whole-genome studies.
Journal ArticleDOI
Principal components analysis corrects for stratification in genome-wide association studies
Alkes L. Price,Alkes L. Price,Nick Patterson,Robert M. Plenge,Robert M. Plenge,Michael E. Weinblatt,Nancy A. Shadick,David Reich,David Reich +8 more
TL;DR: This work describes a method that enables explicit detection and correction of population stratification on a genome-wide scale and uses principal components analysis to explicitly model ancestry differences between cases and controls.
Journal ArticleDOI
The cardiovascular health study: Design and rationale
Linda P. Fried,Nemat O. Borhani,Paul L. Enright,Curt D. Furberg,Julius M. Gardin,Richard A. Kronmal,Lewis H. Kuller,Teri A. Manolio,Maurice B. Mittelmark,Anne B. Newman,Daniel H. O'Leary,Bruce M. Psaty,Pentti M. Rautaharju,Russell P. Tracy,Philip G. Weiler +14 more
TL;DR: These examinations in CHS permit evaluation of CVD risk factors in older adults, particularly in groups previously under-represented in epidemiologic studies, such as women and the very old.
Journal ArticleDOI
Executive Summary: Heart Disease and Stroke Statistics—2010 Update
Donald M. Lloyd-Jones,Robert J. Adams,Todd M. Brown,Mercedes R. Carnethon,Shifan Dai,Giovanni de Simone,T. Bruce Ferguson,Earl S. Ford,Karen L. Furie,Cathleen Gillespie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Susan M. Hailpern,P. Michael Ho,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Lynda D. Lisabeth,Ariane Marelli,Mary M. McDermott,James B. Meigs,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Véronique L. Roger,Wayne D. Rosamond,Ralph L. Sacco,Paul D. Sorlie,Randall S. Stafford,Thomas Thom,Sylvia Wasserthiel-Smoller,Nathan D. Wong,Judith Wylie-Rosett +34 more
TL;DR: Each year, the American Heart Association brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update.
Related Papers (5)
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Nora Franceschini,Claudia Giambartolomei,P. De Vries,Chris Finan,J. C. Bis,Rachael P. Huntley,Ruth C. Lovering,Salman M. Tajuddin,Thomas W. Winkler,Misa Graff,Maryam Kavousi,Caroline Dale,Albert V. Smith,Edith Hofer,E. C. M. van Leeuwen,Ilja M. Nolte,L Lu,Markus Scholz,Muralidharan Sargurupremraj,Niina Pitkänen,Oscar Franzén,Peter K. Joshi,Raymond Noordam,Riccardo E. Marioni,Hwang S-J.,Solomon K. Musani,Ulf Schminke,Walter Palmas,Aaron Isaacs,Adolfo Correa,Alan B. Zonderman,Albert Hofman,Alexander Teumer,Amanda J. Cox,André G. Uitterlinden,Andrew Wong,Andries J. Smit,Anne B. Newman,Annie Britton,Arno Ruusalepp,Bengt Sennblad,Bo Hedblad,Bogdan Pasaniuc,Brenda W.J.H. Penninx,Carl D. Langefeld,Christina L. Wassel,Christophe Tzourio,Cristiano Fava,Cristiano Fava,Damiano Baldassarre,Daniel H. O'Leary,Daniel Teupser,Diana Kuh,Elena Tremoli,Elmo Mannarino,Enzo Grossi,Eric Boerwinkle,Eric Boerwinkle,Eric E. Schadt,Erik Ingelsson,Fabrizio Veglia,Fernando Rivadeneira,Frank Beutner,Ganesh Chauhan,Ganesh Chauhan,Gerardo Heiss,Harold Snieder,Harry Campbell,Henry Völzke,Hugh S. Markus,Ian J. Deary,Joop Jukema,J. de Graaf,Jenna Price,Janne Pott,Jemma C. Hopewell,Jingjing Liang,Joachim Thiery,Jorgen Engmann,Karl Gertow,Kenneth Rice,Kent D. Taylor,Klodian Dhana,Kiemeney Lalm.,Lars Lind,Laura M. Raffield,Lenore J. Launer,Lesca M. Holdt,Lesca M. Holdt,Marcus Dörr,Martin Dichgans,Matthew Traylor,Matthias Sitzer,Meena Kumari,Meena Kumari,Mika Kivimäki,Mike A. Nalls,Olle Melander,Olli T. Raitakari,Olli T. Raitakari,Oscar H. Franco,Oscar H. Franco,Oscar L. Rueda-Ochoa,Oscar L. Rueda-Ochoa,Panos Roussos,Panos Roussos,Peter H. Whincup,P. Amouyel,P. Giral,P Anugu,Quenna Wong,Rainer Malik,Rainer Rauramaa,Ralph Burkhardt,Ralph Burkhardt,Rebecca Hardy,Reinhold Schmidt,R. de Mutsert,Richard W Morris,Rona J. Strawbridge,Rona J. Strawbridge,SG Wannamethee,Sara Hägg,Sonia Shah,Stela McLachlan,Stella Trompet,Sudha Seshadri,Sudhir Kurl,Susan R. Heckbert,Susan R. Heckbert,Susan M. Ring,T.B. Harris,Terho Lehtimäki,Tessel E. Galesloot,Tina Shah,U de Faire,Vincent Plagnol,Wayne D. Rosamond,Wendy S. Post,Xiaofeng Zhu,Xiaoling Zhang,Xuejiang Guo,Yasaman Saba,Abbas Dehghan,Abbas Dehghan,A Seldenrijk,A C Morrison,Anders Hamsten,Bruce M. Psaty,C.M. van Duijn,Debbie A Lawlor,Dennis O. Mook-Kanamori,Donald W. Bowden,Helena Schmidt,James F. Wilson,James G. Wilson,Jerome I. Rotter,Joanna M. Wardlaw,John E. Deanfield,Julian Halcox,Lyytikäinen L-P.,Markus Loeffler,Michelle K. Evans,Stéphanie Debette,S.E. Humphries,Uwe Völker,Vilmundur Gudnason,Aroon D. Hingorani,Björkegren Jlm.,Juan P. Casas,Christopher J. O'Donnell +170 more
Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts
Vesna Boraska,Aaron G. Day-Williams,Christopher S. Franklin,Katherine S. Elliott,Kalliope Panoutsopoulou,Ioanna Tachmazidou,Eva Albrecht,Stefania Bandinelli,Lawrence J. Beilin,Murielle Bochud,Gemma Cadby,Florian Ernst,David M. Evans,Caroline Hayward,Andrew A. Hicks,Jennifer E. Huffman,Cornelia Huth,Alan James,Norman Klopp,Ivana Kolcic,Zoltán Kutalik,Debbie A Lawlor,Arthur W. Musk,Marina Pehlić,Craig E. Pennell,John R. B. Perry,Annette Peters,Ozren Polasek,Beate St Pourcain,Susan M. Ring,Erika Salvi,Sabine Schipf,Jan A. Staessen,Alexander Teumer,Nicholas J. Timpson,Veronique Vitart,Nicole M. Warrington,Hanieh Yaghootkar,Tatijana Zemunik,Lina Zgaga,Ping An,Verneri Anttila,Ingrid B. Borecki,Jostein Holmen,Ioanna Ntalla,Aarno Palotie,Kirsi H. Pietiläinen,Juho Wedenoja,Bendik S. Winsvold,George Dedoussis,Jaakko Kaprio,Michael A. Province,John-Anker Zwart,Michel Burnier,Harry Campbell,Daniele Cusi,George Davey Smith,Timothy M. Frayling,Christian Gieger,Lyle J. Palmer,Peter P. Pramstaller,Igor Rudan,Henry Voelzke,H.-Erich Wichmann,Alan F. Wright,Eleftheria Zeggini +65 more
Lack of Associations of Ten Candidate Coronary Heart Disease Risk Genetic Variants and Subclinical Atherosclerosis in Four U.S. Populations: the Population Architecture using Genomics and Epidemiology (PAGE) Study
Lili Zhang,Lili Zhang,Petra Buzkova,Christina L. Wassel,Mary J. Roman,Kari E. North,Dana C. Crawford,Jonathan Boston,Kristin Brown-Gentry,Shelley A. Cole,Ewa Deelman,Robert Goodloe,Sarah Wilson,Gerardo Heiss,Nancy S. Jenny,Neal W. Jorgensen,Tara C. Matise,Bob McClellan,Alejandro Q. Nato,Marylyn D. Ritchie,Nora Franceschini,W. H. Linda Kao +21 more