MicroRNA related polymorphisms and breast cancer risk
Sofia Khan,Dario Greco,Dario Greco,Kyriaki Michailidou,Roger L. Milne,Roger L. Milne,Taru A. Muranen,Tuomas Heikkinen,Kirsimari Aaltonen,Joe Dennis,Manjeet K. Bolla,Jianjun Liu,Per Hall,Astrid Irwanto,Keith Humphreys,Jingmei Li,Kamila Czene,Jenny Chang-Claude,Rebecca Hein,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Olivia Fletcher,Julian Peto,Isabel dos Santos Silva,Nichola Johnson,Lorna Gibson,Zoe Aitken,John L. Hopper,Helen Tsimiklis,Minh Bui,Enes Makalic,Daniel F. Schmidt,Melissa C. Southey,Carmel Apicella,Jennifer Stone,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Alfons Meindl,Rita K. Schmutzler,Bertram Müller-Myhsok,Peter Lichtner,Clare Turnbull,Nazneen Rahman,Stephen J. Chanock,David J. Hunter,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Marjanka K. Schmidt,Annegien Broeks,Laura Van't Veer,Frans B. L. Hogervorst,Peter A. Fasching,Michael G. Schrauder,Arif B. Ekici,Matthias W. Beckmann,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Javier Benitez,Pilar Zamora,Jose Ignacio Arias Perez,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Paul D.P. Pharoah,Alison M. Dunning,Mitul Shah,Robert Luben,Judith E. Brown,Fergus J. Couch,Xianshu Wang,Celine M. Vachon,Janet E. Olson,Diether Lambrechts,Matthieu Moisse,Robert Paridaens,Marie-Rose Christiaens,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Claire Mulot,F Marmé,Barbara Burwinkel,Andreas Schneeweiss,Christof Sohn,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Irene L. Andrulis,Julia A. Knight,Sandrine Tchatchou,Anna Marie Mulligan,Thilo Dörk,Natalia Bogdanova,Natalia Antonenkova,Hoda Anton-Culver,Hatef Darabi,Mikael Eriksson,Montserrat Garcia-Closas,Jonine D. Figueroa,Jolanta Lissowska,Louise A. Brinton,Peter Devilee,Robert A.E.M. Tollenaar,Caroline Seynaeve,Christi J. van Asperen,Vessela N. Kristensen,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Annika Lindblom,Sara Margolin,Paolo Radice,Paolo Peterlongo,Monica Barile,Paolo Mariani,Maartje J. Hooning,John W.M. Martens,J. Margriet Collée,Agnes Jager,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Graham G. Giles,Catriona McLean,Hiltrud Brauch,Thomas Brüning,Yon-Dschun Ko,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Michael Jones,Jacques Simard,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Arto Mannermaa,Ute Hamann,Georgia Chenevix-Trench,Carl Blomqvist,Kristiina Aittomäki,Douglas F. Easton,Heli Nevanlinna +161 more
TLDR
Five miRNA binding site SNPs associated significantly with breast cancer risk are located in the 3′ UTR of CASP8, HDDC3, DROSHA, MUSTN1, and MYCL1, respectively, which belongs to miRNA machinery genes and has a central role in initial miRNA processing.Citations
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A worldwide phylogenetic classification of the Poaceae (Gramineae)
Robert J. Soreng,Paul M. Peterson,Konstantin Romaschenko,Gerrit Davidse,Fernando O. Zuloaga,Emmet J. Judziewicz,Tarciso S. Filgueiras,Jerrold I. Davis,Osvaldo Morrone +8 more
TL;DR: Based on recent molecular and morphological studies, this work presents a modern worldwide phylogenetic classification of the 771 grass genera and divides them into 12 subfamilies.
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Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation.
Laween Uthman,Antonius Baartscheer,Boris Bleijlevens,Cees A. Schumacher,Jan W.T. Fiolet,Anneke Koeman,Milena Jancev,Markus W. Hollmann,Nina C. Weber,Ruben Coronel,Coert J. Zuurbier +10 more
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Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy.
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Lep-MAP3: robust linkage mapping even for low-coverage whole genome sequencing data.
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Psychological health, sleep quality, and coping styles to stress facing the COVID-19 in Wuhan, China.
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References
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Journal ArticleDOI
A combined analysis of genome-wide association studies in breast cancer
Jingmei Li,Jingmei Li,Keith Humphreys,Tuomas Heikkinen,Kristiina Aittomäki,Carl Blomqvist,Paul D.P. Pharoah,Alison M. Dunning,Shahana Ahmed,Maartje J. Hooning,John W. M. Martens,Ans M.W. van den Ouweland,Lars Alfredsson,Aarno Palotie,Leena Peltonen-Palotie,Astrid Irwanto,Hui Qi Low,Garrett H. K. Teoh,Anbupalam Thalamuthu,Douglas F. Easton,Heli Nevanlinna,Jianjun Liu,Kamila Czene,Per Hall +23 more
TL;DR: The results suggest that further analysis of SNPs in genes in specific pathways may identify associations that would be difficult to detect through agnostic single SNP analyses, and more effort focused in these aspects of oncology can potentially open up promising avenues for the understanding of breast cancer and its prevention.
A combined analysis of genome-wide association studies in breast cancer
Jingmei Li,Jingmei Li,Keith Humphreys,Tuomas Heikkinen,Kristiina Aittomäki,Carl Blomqvist,Paul D.P. Pharoah,Alison M. Dunning,Shahana Ahmed,Maartje J. Hooning,John W. M. Martens,Ans M.W. van den Ouweland,Lars Alfredsson,Aarno Palotie,Leena Peltonen-Palotie,Astrid Irwanto,Hui Qi Low,Garrett H. K. Teoh,Anbupalam Thalamuthu,Douglas F. Easton,Heli Nevanlinna,Jianjun Liu,Kamila Czene,Per Hall +23 more
TL;DR: In an attempt to identify common disease susceptibility alleles for breast cancer, the authors performed a combined analysis of three genome-wide association studies (GWAS), involving 2,702 women of European ancestry with invasive breast cancer and 5,726 controls.
Journal ArticleDOI
Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
TL;DR: The results demonstrated that 10 associations were noteworthy: CASP8 (D302H), CHEK2 (*1100delC), CTLA4 (+49G>A), FGFR2 (rs2981582, rs1219648, and rs2420946), HRAS (rare alleles), IL1B (rs1143627), LSP1 (rs3817198), and MAP3K1 (RS889312).
Journal ArticleDOI
Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer.
Fang Xiong,Chen Wu,Jiang Chang,Dianke Yu,Binghe Xu,Peng Yuan,Kan Zhai,Jian Xu,Wen Tan,Dongxin Lin +9 more
TL;DR: A 3'-UTR SNP in the human L-MYC oncogene that may increase susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827 is defined.
Journal ArticleDOI
Amplification and Overexpression of the L-MYC Proto-Oncogene in Ovarian Carcinomas
Rong Wu,Lin Lin,David G. Beer,Lora Hedrick Ellenson,Barbara J. Lamb,Jean Marie Rouillard,Rork Kuick,Samir M. Hanash,Donald R. Schwartz,Eric R. Fearon,Kathleen R. Cho +10 more
TL;DR: Limiting landmark genomic scanning (RLGS) was used to detect amplified DNA fragments in the genomes of 47 primary OvCas, finding that L-MYC was found to be more frequently overexpressed in OvCas than either c-myC or N- MYC relative to ovarian surface epithelium.
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