Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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Genomic landscape of the SARS-CoV-2 pandemic in Brazil suggests an external P.1 variant origin
TL;DR: In this paper , the authors track SARS-CoV-2 molecular information in Brazil using real-time bioinformatics and data science strategies to provide a comparative and evolutive panorama of the lineages in the country.
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SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021.
Mohammad Alkhatib,Valentina Svicher,R. Salpini,Francesca Alessandra Ambrosio,Maria Concetta Bellocchi,L. Carioti,Lorenzo Piermatteo,Rossana Scutari,Giosuè Costa,Anna Artese,Stefano Alcaro,Robert W. Shafer,F. Ceccherini-Silberstein +12 more
TL;DR: In this article, the authors provide a comprehensive insight into mutational profiles characterizing each SARS-CoV-2 variant, focusing on spike mutations known to modulate viral infectivity and/or antigenicity.
Posted ContentDOI
Topology identifies emerging adaptive mutations in SARS-CoV-2
Michael Bleher,Lukas Hahn,Juan Ángel Patiño-Galindo,Mathieu Carrière,Ulrich Bauer,Raul Rabadan,Andreas Ott,Andreas Ott +7 more
TL;DR: In this article, a topological data analysis approach for early warning and surveillance of emerging adaptive mutations of the coronavirus SARS-CoV-2 in the ongoing COVID-19 pandemic is presented.
Book ChapterDOI
RNA as modulators of infection outcome
TL;DR: In this article , the authors discuss how whole genome data is made available, and various approaches and methods such as whole genome sequencing and phylodynamic analysis, especially to monitor rapidly evolving RNA viral diseases.
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