Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display
Shiho Tanaka,C. Anders Olson,Christopher O. Barnes,Wendy Higashide,Marcos Gonzalez,Justin Taft,Ashley Richardson,Marta Martín-Fernández,Dusan Bogunovic,Priyanthi N. P. Gnanapragasam,Pamela J. Bjorkman,Patricia Spilman,Kayvan Niazi,Shahrooz Rabizadeh,Patrick Soon-Shiong +14 more
TL;DR: In this article, a set of antibodies against SARS-CoV-2 spike (S) proteins and characterized the structures of nAbs that recognized epitopes in the S1 subunit of the S glycoprotein.
Journal ArticleDOI
Paired Heavy and Light Chain Signatures Contribute to Potent SARS-CoV-2 Neutralization in Public Antibody Responses
Bailey B. Banach,Gabriele Cerutti,Ahmed S. Fahad,Chen-Hsiang Shen,Matheus Oliveira de Souza,Phinikoula S. Katsamba,Yaroslav Tsybovsky,Pengfei Wang,Manoj S. Nair,Yaoxing Huang,Irene M. Francino Urdániz,Paul J. Steiner,Matias Gutiérrez-González,Lihong Liu,Sheila N. Lopez Acevedo,Alexandra Nazzari,Jacy R. Wolfe,Yang Luo,Adam S. Olia,I-Ting Teng,Jian Yu,Tongqing Zhou,Eswar R. Reddem,Jude Bimela,Xiaoli Pan,Bharat Madan,Amy D. Laflin,Rajani Nimrania,Kwok-Yung Yuen,Timothy A. Whitehead,David D. Ho,Peter D. Kwong,Lawrence Shapiro,Brandon J. DeKosky +33 more
TL;DR: Key structural and functional neutralization features of the IGHV3-53/3-66 public antibody class are revealed to accelerate antibody-based efforts against SARS-CoV-2.
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Uncovering Ways That Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Lineages May Increase Transmissibility.
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Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacy
TL;DR: The authors summarized existing evidence about newly emerged variants of SARS-CoV-2 and how well vaccines work against targeting new variants and modifications of highly flexible mRNA vaccines that might be required in the future.
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The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model
Maxime Cochin,Léa Luciani,Franck Touret,Jean-Sélim Driouich,Paul-Rémi Petit,Gregory Moureau,Cécile Baronti,Caroline Laprie,Laurence Thirion,Piet Maes,Robbert Boudewijns,Johan Neyts,Xavier de Lamballerie,Antoine Nougairède +13 more
TL;DR: In this article , the authors used a Syrian hamster model to compare a clinical strain of Alpha variant with an ancestral G614 strain and found that both strains replicate to almost the same level and induced a comparable disease and immune response.
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