Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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An Intranasal OMV-based vaccine induces high mucosal and systemic protecting immunity against a SARS-CoV-2 infection
TL;DR: In this article, an intranasal COVID-19 subunit vaccine, based on a recombinant, six proline stabilized, D614G spike protein (mC-Spike) of SARS-CoV-2 linked via the LPS-binding peptide sequence mCramp to Outer Membrane Vesicles (OMVs) from Neisseria meningitidis, was developed.
Journal ArticleDOI
The Emergence of SARS-CoV-2 Variants With a Lower Antibody Response: A Genomic and Clinical Perspective
Suvro Biswas,Shafi Mahmud,Mohasana Akter Mita,Shamima Afrose,Md. Robiul Hasan,Gobindo Kumar Paul,M. S. S. Shimu,Md. Salah Uddin,Shahriar Zaman,Moon Nyeo Park,Abolghasem Siyadatpanah,Ahmad J. Obaidullah,Md. Abu Saleh,Jesus Simal-Gandara,Bonglee Kim +14 more
TL;DR: In this article , the authors review the genomic variation and pandemic impact of emerging variations of concern based on clinical characteristics management and immunization effectiveness, and gain a better understanding of the link between genome level polymorphism, clinical symptom manifestation, and current vaccination in the instance of VOCs.
Journal ArticleDOI
Probing the mutational landscape of the SARS-CoV-2 spike protein via quantum mechanical modeling of crystallographic structures
Marco Zaccaria,Luigi Genovese,William Dawson,Viviana Cristiglio,Takahito Nakajima,Welkin E. Johnson,Michael Farzan,Babak Momeni +7 more
TL;DR: Broad agreement between the QM-CR predictions and experimental evidence supports the notion that ab initio modeling has now reached the maturity to handle large intermolecular interactions central to biological processes.
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Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
Lukas Wettstein,Philip Maximilian Knaff,Christian Kersten,Patrick Müller,Tanja Weil,Carina Conzelmann,Janis A. Müller,Maximilian Brückner,Markus Hoffmann,Stefan Pöhlmann,Tanja Schirmeister,Katharina Landfester,Jan Münch,Volker Mailänder +13 more
TL;DR: In this article , the authors describe the in-silico development and in vitro characterization of peptidomimetic transmembrane serine protease 2 (TMPRSS2) inhibitors and demonstrate good off-target selectivity against selected coagulation proteases.
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Mulberry Component Kuwanon C Exerts Potent Therapeutic Efficacy In Vitro against COVID-19 by Blocking the SARS-CoV-2 Spike S1 RBD:ACE2 Receptor Interaction
TL;DR: This study tested the effectiveness of kuwanon C (KC), which has been researched using in silico docking simulation and can serve as an effective building block for developing anti-COVID-19 drugs, in blocking the spike S1 RBD:ACE2 receptor interaction and established a mechanism of action.
References
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