Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
Citations
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SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants
Fiona Tea,Alberto Ospina Stella,Anupriya Aggarwal,D.R. Darley,D.R. Darley,Deepti Pilli,Daniele Vitale,Vera Merheb,Fiona X Z Lee,Philip Cunningham,Gregory J. Walker,David Brown,William D. Rawlinson,Sonia R Isaacs,Vennila Mathivanan,Markus Hoffman,Stefan Pöhlmann,Dominic E. Dwyer,Dominic E. Dwyer,Rebeca Rockett,Rebeca Rockett,Vitali Sintchenko,Veronica C. Hoad,David O. Irving,Gregory J. Dore,Gregory J. Dore,Iain B Gosbell,Iain B Gosbell,Anthony D. Kelleher,Gail V. Matthews,Gail V. Matthews,Fabienne Brilot,Stuart Turville +32 more
TL;DR: In this article, a broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization were associated with COVID-19 severity.
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Impact of the Double Mutants on Spike Protein of SARS-CoV-2 B.1.617 Lineage on the Human ACE2 Receptor Binding: A Structural Insight.
Mohd Imran Khan,Mohammad Hassan Baig,Tanmoy Mondal,Mohammed Alorabi,Tanuj Sharma,Jae June Dong,Jae Yong Cho +6 more
TL;DR: In this article, the authors investigated the impact of double mutations carried by SARS-CoV-2 variants on the binding capability to the human host receptor and found that these double mutants might be a dominant contributor enhancing the receptor-binding affinity.
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Distinct neutralizing kinetics and magnitudes elicited by different SARS-CoV-2 variant spikes
TL;DR: In this paper, the authors report that immunization with different variant spikes elicits distinct neutralizing kinetics and magnitudes against other SARS-CoV-2 variants, including Delta and Alpha, Beta, Gamma, or Epsilon.
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Neutral evolution test of the spike protein of SARS-CoV-2 and its implications in the binding to ACE2.
Georgina I. López-Cortés,Miryam Palacios-Pérez,Gabriel S. Zamudio,Hannya F. Veledíaz,Hannya F. Veledíaz,Enrique Ortega,Marco V. José +6 more
TL;DR: A neutrality test shows that most unique mutations either for SARS-CoV-2 or the variants of health concern are under selective pressures, which could be related either to the evasion of the immune system, increasing the virus’ fitness or altering protein – protein interactions with host proteins.
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SARS-CoV-2: vaccinology and emerging therapeutics; challenges and future developments
TL;DR: This viewpoint advocates for countries to conduct prior efficacy studies before they embark on mass vaccination and addresses the role of nanoparticles as carrier vehicles for these vaccines with a view to explore the present challenges and forge a path for a stronger and more viable future for the development of vaccines for SARS-CoV-2 and future pandemics.
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