Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
Citations
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SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact
TL;DR: In this paper, the authors used molecular dynamics simulations and two-dimensional replica exchange umbrella sampling calculations to investigate the transition between the two S-protein conformations with and without glycosylation.
Patent
Stabilized Coronavirus Spike (S) Protein Immunogens and Related Vaccines
TL;DR: In this article, a redesigned soluble coronavirus S protein derived immunogens are stabilized via specific modifications in the wild type soluble S sequences and also provided nanoparticle vaccines that contain the redesigned S immunogens displayed on selfassembling nanoparticles.
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Investigating the possible origin and transmission routes of SARS-CoV-2 genomes and variants of concern in Bangladesh
Abdullah Al Nahid,Ajit Ghosh +1 more
TL;DR: In this paper, the authors analyzed publicly available genomic data to understand the current COVID-19 outbreak scenario as well as the evolutionary origin and transmission routes of SARS-CoV-2 isolates in Bangladesh.
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Initiation of neutralizing antibody response probed using synthetic virus-like structures
Wei-Yun Wholey,Alexander R. Meyer,Sekou-Tidiane Yoda,Bryce Chackerian,Julie Zikherman,Wei Cheng +5 more
TL;DR: In this article , a reductionist system of synthetic virus-like structures (SVLS) containing minimal, highly purified biochemical components commonly found in enveloped viruses was used to demonstrate a generalized mechanism for nAb induction in mice, with the minimal structures of viruses alone being potent inducers of nAb, without viral replication or any other components.
Journal ArticleDOI
Use of Polymer Micropillar Arrays as Templates for Solid-Phase Immunoassays
Matthias Geissler,André Ponton,Christina Nassif,Lidija Malic,Karine Turcotte,Ljuboje Lukic,Keith Morton,Teodor Veres +7 more
TL;DR: It is suggested that signal intensity scales proportionally with the 3D surface area available for performing solid-phase immunoassays, opening the possibility of tuning assay response by design such that desired signal intensity is obtained over a wide dynamic range compatible with different assays, analyte concentrations, and readout instruments.
References
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