Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Emily A. Voigt,Alana Gerhardt,Derek J. Hanson,Peter Battisti,Sierra A. Reed,Jas Singh,Raodoh Mohamath,Madeleine F. Jennewein,Julie Bakken,Sam Beaver,Chris Press,Patrick Soon-Shiong,Chris J. Paddon,Christopher Cox,Corey Casper +14 more
TL;DR: In this article , the authors developed an easily-manufactured, potent self-amplifying RNA (saRNA) vaccine against SARS-CoV-2 that is stable at room temperature.
Journal ArticleDOI
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike
Xiaoli Xiong,Alcimar B. Soares +1 more
TL;DR: In this paper , a SARS-CoV-2 S protein construct called S-R/x3 was constructed to stabilize the lock-1 and lock-2 conformation.
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SARS-CoV-2 receptor-binding mutations and antibody contact sites
TL;DR: In this paper, a bioinformatics platform was developed to analyze 104 193 Global Initiative on Sharing All Influenza Data (GISD) data sequences acquired on 15 October 2020, with a majority of sequences (96%) containing point mutations.
Posted ContentDOI
Analysis of SARS-CoV-2 Mutations Over Time Reveals Increasing Prevalence of Variants in the Spike Protein and RNA-Dependent RNA Polymerase
TL;DR: In this article, a structural analysis of the SARS-CoV-2 virus was performed at the protein structural level and examined longitudinally in order to identify sequence and strain variants that are emerging over time.
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New laboratory evidence for the association between endothelial dysfunction and COVID‐19 disease progression
Nan Liu,Hui Long,Jianhua Sun,Huan Li,Yun-Ting He,Liang Wang,Kai Pan,Yongliang Tong,Bing-Shun Wang,Qing-Qing Wu,Likun Gong +10 more
TL;DR: A multicenter retrospective cohort of 966 COVID‐19 patients from three hospitals in Wuhan, China found that deteriorated patients exhibited more severe multiorgan damage, coagulation dysfunction, and extensive inflammation, which offers a rationale for targeting endothelial dysfunction as a therapeutic strategy for CO VID‐19.
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