Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies
Yifan Wang,Caixuan Liu,Chao Zhang,Yanxing Wang,Qin Hong,Shiqi Xu,Zuyang Li,Yong Yang,Zhong-Liang Huang,Yao Cong +9 more
TL;DR: In this paper , the structural basis of the enhanced transmission and altered immune sensitivity of the SARS-CoV-2 Delta variant is uncovered. But the structure of the Delta T478K substitution plays a vital role in stabilizing and reshaping the RBM loop473-490, enhancing interaction with ACE2.
Journal ArticleDOI
V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity.
Junxian Ou,Zhonghua Zhou,Ruixue Dai,Jing Zhang,Shan Zhao,Xiaowei Wu,Wendong Lan,Yi Ren,Lilian Cui,Qiaoshuai Lan,Lu Lu,Donald Seto,James Chodosh,Jianguo Wu,Gong Zhang,Qiwei Zhang,Qiwei Zhang +16 more
TL;DR: In this paper, the binding dynamics between SARS-CoV-2 RBD mutants and the human angiotensin-converting enzyme 2 (ACE2) receptor were analyzed in silico.
Journal ArticleDOI
SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations.
TL;DR: The SARS-CoV-2 variant of concern (VOC)-202012/01 (also known as B.1.7), first collected in United Kingdom on 20 September 2020, is a rapidly growing lineage that in January 2021 constituted 86% of all SARS CoV2 genomes sequenced in England.
Journal ArticleDOI
The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines
Gary R. McLean,Jeremy P. Kamil,Benhur Lee,Penny L. Moore,Thomas G. Schulze,Alexander Muik,Ugur Sahin,Özlem Türeci,Shanti Pather +8 more
TL;DR: Evidence suggests that T-cell responses are preserved across vaccine platforms, regardless of variant of concern, which suggests the potential for reduced efficacy or effectiveness against current and future SARS-CoV-2 variants is low.
Journal ArticleDOI
The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.
TL;DR: How the D614G variant was identified was identified and recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response is discussed.
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