Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
Citations
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Molecularly Imprinted Polypyrrole based Sensor for the Detection of SARS-CoV-2 Spike Glycoprotein
Vilma Ratautaite,Raimonda Boguzaite,Ernestas Brazys,Almira Ramanaviciene,Evaldas Čiplys,Mindaugas Juozapaitis,Rimantas Slibinskas,Mikhael Bechelany,Arunas Ramanavicius +8 more
TL;DR: In this article, the application of a polypyrrole-based sensor for the determination of SARS-CoV-2-S spike glycoprotein was described, and the performance of polymer layers was evaluated by pulsed amperometric detection (CA).
Journal ArticleDOI
Molecularly imprinted polypyrrole based sensor for the detection of SARS-CoV-2 spike glycoprotein
TL;DR: In this article , the application of a polypyrrole-based sensor for the determination of SARS-CoV-2-S spike glycoprotein was described, and the performance of polymer layers was evaluated by pulsed amperometric detection.
Posted ContentDOI
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants
TL;DR: The SARS-CoV-2 Spike protein needs to be in an open-state conformation to interact with ACE2 as part of the viral entry mechanism, and coarse-grained normal-mode analyses are used to model the dynamics of Spike and calculate transition probabilities between states for 17081 Spike variants.
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SARS-CoV-2 spike P681R mutation enhances and accelerates viral fusion
Akatsuki Saito,Rigel Suzuki,Rigel Suzuki,Tadashi Maemura,Hesham Nasser,Hesham Nasser,Keiya Uriu,Yusuke Kosugi,Kotaro Shirakawa,Kenji Sadamasu,Izumi Kimura,Jumpei Ito,Jiaqi Wu,Kiyoko Iwatsuki-Horimoto,Mutsumi Ito,Seiya Yamayoshi,Seiya Ozono,Erika P Butlertanaka,Yuri L Tanaka,Ryo Shimizu,Kenta Shimizu,Kumiko Yoshimatsu,Ryoko Kawabata,Takemasa Sakaguchi,Kenzo Tokunaga,Isao Yoshida,Hiroyuki Asakura,Mami Nagashima,Yasuhiro Kazuma,Ryosuke Nomura,Yasuhito Horisawa,Kazuhisa Yoshimura,Akifumi Takaori-Kondo,Masaki Imai,So Nakagawa,Terumasa Ikeda,Takasuke Fukuhara,Yoshihiro Kawaoka,Kei Sato +38 more
TL;DR: In this paper, the authors show that the P681R mutation facilitates the furin-mediated spike cleavage and enhances and accelerates cell-cell fusion in the B.1.617 lineage.
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An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity
Chihiro Motozono,Mako Toyoda,Jiri Zahradnik,Terumasa Ikeda,Akatsuki Saito,Toong Seng Tan,Isaac Ngare,Hesham Nasser,Izumi Kimura,Keiya Uriu,Yusuke Kosugi,Shiho Torii,Akiko Yonekawa,Nobuyuki Shimono,Yoji Nagasaki,Rumi Minami,Takashi Toya,Noritaka Sekiya,Takasuke Fukuhara,Yoshiharu Matsuura,Gideon Schreiber,So Nakagawa,Takamasa Ueno,Kei Sato +23 more
TL;DR: In this paper, two recently emerging mutants in the receptor binding domain of the SARS-CoV-2 spike protein, L452R (in B.1.427/429) and Y453F, can escape from the HLA-24-restricted cellular immunity.
References
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