Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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D614G and SARS-CoV-2 replication fitness.
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COVID-19: A Systematic Review of the Transmissibility, Pathogenesis, Entry Factors, and Signature Immune Response
TL;DR: A systematic review of the literature was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to gain insight into the transmissibility, pathogenesis, entry factors, and immune response of COVID-19 as mentioned in this paper .
Journal ArticleDOI
Analyses of Long-Term Epidemic Trends and Evolution Characteristics of Haplotype Subtypes Reveal the Dynamic Selection on SARS-CoV-2
Binbin Xi,Yuhuan Meng,Dawei Jiang,Yunmeng Bai,Zixi Chen,Yimo Qu,Shuhua Li,Jinfen Wei,Lizhen Huang,Hongli Du +9 more
TL;DR: The present study analyzed the epidemic and evolutionary characteristics of haplotype subtypes or regions based on 1.8 million high-quality SARS-CoV-2 genomic data to show its transmissibility and the ability of immune escape may be greatly enhanced over time.
Journal ArticleDOI
An Electrostatically-steered Conformational Selection Mechanism Promotes SARS-CoV-2 Spike Protein Variation
M. A. Sorokina,Jaydeep Belapure,Christian Tüting,Reinhard Paschke,Ioannis Papasotiriou,João P. G. L. M. Rodrigues,Panagiotis L. Kastritis +6 more
TL;DR: In this paper , the authors analyzed the evolution of the S protein as recorded in 276,712 samples collected before the start of vaccination efforts and found that most variants of SARS-CoV-2 variants with substitutions on the spike (S) protein increase the risk of immune evasion and cross-species transmission.
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Investigating expressed RNA variants that are related to disease severity in SARS-CoV-2-infected patients with mild-to-severe disease
Javan Okendo,David Okanda +1 more
TL;DR: In this article , the authors characterized the different expressed RNAseq variants in healthy, severe, moderate, ICU, and convalescent individuals and showed that the individuals who recover from SARS-CoV-2 infection have the same set of expressed variants as the healthy controls.
References
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