Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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Whole Genome Sequencing Analysis of Spike D614G Mutation Reveals Unique SARS-CoV-2 Lineages of B.1.524 and AU.2 in Malaysia
Ummu Afeera Zainulabid,Ummu Afeera Zainulabid,Aini Syahida Mat Yassim,Sharmeen Nellisa Soffian,Mohamad Shafiq Mohd Ibrahim,Norhidayah Kamarudin,Mohd Nazli Kamarulzaman,How Soon Hin,Hajar Fauzan Ahmad +8 more
TL;DR: In this article, the authors reported new Malaysian lineages responsible for the sustained spikes in COVID-19 cases during the third wave of the pandemic, and they used real-time RT-PCR with Ct-value < 25 for WGS.
Journal ArticleDOI
Uncovering of the Evolutionary Relationship of SARS-COV-2 by Analyzing 13 Genomic Sequences
TL;DR: It is suggested that spike protein plays a key role in the processing of viral infection and the evolution of the SARS-CoV-2, which may provide several novel clues for researchers to study the morbidity or infectivity of the virus and to find the strategies to control it in the near future.
Journal ArticleDOI
A bibliometric analysis of the 100 most cited articles describing SARS-CoV-2 variants
TL;DR: Genomics information, epidemiology, immune neutralization, and vaccine efficacy studies of COVID-19 variants are the main research orientations in these articles and relevant results have been published in influential journals.
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The Quantification of Spike Proteins in the Inactivated SARS-CoV-2 Vaccines of the Prototype, Delta, and Omicron Variants by LC–MS
TL;DR: In this paper , a method based on LC-MS was established to quantify the S proteins in inactivated monovalent vaccines or trivalent vaccines (prototype, Delta, and Omicron strains).
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