Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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A highly immunogenic live-attenuated vaccine candidate prevents SARS-CoV-2 infection and transmission in hamsters
Xiaofeng Li,Zhen Cui,Hang Fan,Qi Chen,Lei Cao,Hong-Ying Qiu,Na-Na Zhang,Yan Peng Xu,Rong Rong Zhang,Chao Zhou,Qing Ye,Yong-Qiang Deng,Yan Guo,Si Qin,Kaiyue Fan,Lei Wang,Zijing Jia,Yujun Cui,Xiangxi Wang,Cheng-Feng Qin +19 more
TL;DR: Wang et al. as discussed by the authors used a serial passaging of a SARS-CoV-2 clinical isolate in Vero cells to generate a live-attenuated vaccine candidate against COVID-19.
Posted Content
The differential expression of the ACE2 receptor across ages and gender explains the differential lethality of SARS-Cov-2 and suggests possible therapy
TL;DR: The results support the suggestion that drugs that enhance the expression of ACE2, such as ACE inhibitors and angiotensin receptor blockers, constitute a promising therapy against the most adverse effects of CoViD-19, and ACE2 is a candidate prognostic factor for detecting population that needs stronger protection.
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Photonics enabled intelligence system to identify SARS-CoV 2 mutations
Bakr Ahmed Taha,Qussay Al-Jubouri,Yousif I. Al Mashhadany,Mohd Saiful Dzulkefly Zan,Ahmad Ashrif A Bakar,Mahmoud Muhanad Fadhel,Norhana Arsad +6 more
TL;DR: In this article , the authors proposed a framework of photonics based on AI for identifying and sorting SARS-CoV 2 mutations, and compared the omicron mutation with other variants.
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SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response
TL;DR: Wang et al. as mentioned in this paper evaluated the immune properties of the HLA-A2 restricted CD8+ T cell epitopes containing mutations from B.1.7, and furthermore performed a comprehensive analysis of the SARS-CoV-2 specific CD8-T cell responses.
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SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant
TL;DR: Wang et al. as discussed by the authors showed that the representative characteristics of the Omicron spike are determined by its receptor-binding domain, and further elucidated that the F375 residue forms an interprotomer pi-pi interaction with the H505 residue in another protomer in the spike trimer, which confers the attenuated spike cleavage efficiency and fusogenicity.
References
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