Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells
Rayhane Nchioua,Annika Schundner,Dorota Kmieć,Caterina Prelli Bozzo,Fabian Zech,Lennart Koepke,Alexander Graf,Stefan Krebs,Helmut Blum,Manfred Frick,Konstantin M. J. Sparrer,Frank Kirchhoff +11 more
TL;DR: Depletion of endogenous IFITM2 expression almost entirely prevents productive infection of Alpha, Beta, Gamma, Delta, and Omicron SARS-CoV-2 VOCs in human lung cells, suggesting a key proviral role of IFITMs in viral transmission and pathogenicity.
Journal ArticleDOI
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
TL;DR: In this article , the authors examined the contribution of the NTD to infection and cell-cell fusion by constructing chimeric spikes bearing B.1.617 lineage (Delta and Kappa variants) NTDs and generating spike pseudotyped lentivirus.
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Shooting at a Moving Target-Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine Development.
Franziska Günl,Angeles Mecate-Zambrano,Selina Rehländer,Saskia Hinse,Stephan Ludwig,Linda Brunotte +5 more
TL;DR: In this paper, a review summarizes the unprecedented pathways of vaccine development and approval during the ongoing SARS-CoV-2 pandemic and summarizes the timeline of applied adaptations to the recommended vaccination strategies in the light of emerging virus variants.
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19.
Winston A. Haynes,Kathy Kamath,Joel Bozekowski,Elisabeth Baum-Jones,Melissa Campbell,Arnau Casanovas-Massana,Patrick S. Daugherty,Charles S. Dela Cruz,Abhilash Dhal,Shelli F. Farhadian,Lynn Fitzgibbons,John Fournier,Michael Jhatro,Gregory Jordan,Jon Klein,Carolina Lucas,Debra Kessler,Larry L. Luchsinger,Brian Martinez,M. Catherine Muenker,Lauren Pischel,Jack Reifert,Jaymie R Sawyer,Rebecca Waitz,Elsio A. Wunder,Minlu Zhang,Yale Impact Team,Yale Impact Team,Akiko Iwasaki,Akiko Iwasaki,Albert I. Ko,John Shon +31 more
TL;DR: In this article, the Serum Epitope Repertoire Analysis (SERA) platform leverages a high diversity random bacterial display library to identify proteome-independent epitope binding specificities which are then analyzed in the context of organisms of interest.
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Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats
Jin Tian,Jiumeng Sun,Dongyan Li,Ningning Wang,Lifang Wang,Chang Zhang,X.-J. Meng,Xiang Ji,Marc A. Suchard,Xu Zhang,Alexander Lai,Shuo-Bing Su,Michael Veith +12 more
TL;DR: In this paper , the taxonomy, geographic distribution, and unique traits of bats associated with their importance as virus reservoirs are described, and a comparison of these interactions in humans, intermediate hosts, and bats is conducted.
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