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Open AccessJournal ArticleDOI

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.

Leonid Yurkovetskiy, +22 more
- 29 Oct 2020 - 
- Vol. 183, Iss: 3, pp 739
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.
About: 
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.

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Persistence of infectious SARS-CoV-2 particles for up to 37 days in patients with mild COVID-19.

Tobias Zahn, +14 more
- 12 Oct 2021 - 
TL;DR: In this paper, the authors describe three patients who independently acquired their infection and were able to completely recover symptomatically within 10 days, but remained PCR-positive in deep pharyngeal samples for at least 38 days.
Journal ArticleDOI

Genomic Characterization of SARS-CoV-2 Isolated from Patients with Distinct Disease Outcomes in Mexico

Celia Boukadida, +20 more
- 12 Jan 2022 - 
TL;DR: A trait-association phylogenomic approach was used to explore genotype–phenotype associations, represented by the co-occurrence of mutations, disease severity outcome categories, and clusters of Mexican sequences, which revealed a higher genomic diversity compared to the initial viruses detected during the early stage of the local epidemic.
Journal ArticleDOI

High Concentration and Frequent Application of Disinfection Increase the Detection of Methicillin-Resistant Staphylococcus aureus Infections in Psychiatric Hospitals During the COVID-19 Pandemic.

Mi Yang, +5 more
- 01 Jan 2021 - 
TL;DR: In this paper, the authors investigated the mechanisms underlying a sharp increase in the detection of methicillin-resistant Staphylococcus aureus (MRSA) observed in a closed-management unit of elderly patients with mental disorders in 2020 as compared with the previous 4 years.
Posted ContentDOI

Natural variants in SARS-CoV-2 S protein pinpoint structural and functional hotspots; implications for prophylaxis strategies

Daria Mochly-Rosen, +2 more
- 06 Jan 2021 - 
TL;DR: The SARS-CoV-2 viral genome mutates incessantly as it spreads in the world and the gene for the Spike (S) protein, critical for viral transmission into humans, is no exception as mentioned in this paper.
Journal ArticleDOI

Modelling the association between COVID-19 transmissibility and D614G substitution in SARS-CoV-2 spike protein: using the surveillance data in California as an example.

Shi Zhao, +8 more
- 09 Mar 2021 - 
TL;DR: In this article, the authors developed a statistical framework to explore the association between molecular-level mutation activity of SARS-CoV-2 and population-level disease transmissibility of COVID-19.
References
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Journal ArticleDOI

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Heng Li, +8 more
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Chaolin Huang, +28 more
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TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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TL;DR: This version of MAFFT has several new features, including options for adding unaligned sequences into an existing alignment, adjustment of direction in nucleotide alignment, constrained alignment and parallel processing, which were implemented after the previous major update.
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Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

Na Zhu, +18 more
- 24 Jan 2020 - 
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

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