Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:Â
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomes.
Qinglan Sun,Chang Shu,Wenyu Shi,Yingfeng Luo,Fan Guomei,Jingyi Nie,Yuhai Bi,Qihui Wang,Jianxun Qi,Jian Lu,Yuanchun Zhou,Zhihong Shen,Zhen Meng,Xinjiao Zhang,Zhengfei Yu,Shenghan Gao,Linhuan Wu,Juncai Ma,Songnian Hu +18 more
TL;DR: Wang et al. as discussed by the authors established an evaluation and prewarning system, VarEPS, including known and virtual mutations of SARS-CoV-2 genomes to achieve rapid evaluation of the risks posed by mutant strains.
Journal ArticleDOI
Binding and entering: COVID finds a new home.
TL;DR: In this paper, the authors discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS CoV2 to be a pandemic virus.
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End-to-End Protein Normal Mode Frequency Predictions Using Language and Graph Models and Application to Sonification.
Yiwen Hu,Markus J. Buehler +1 more
TL;DR: In this article , an end-to-end LSTM-based transformer model was used to predict the first 64 normal mode frequencies of proteins from the amino acid sequence using graph neural networks.
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Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles
TL;DR: Based on the HIV-1 backbone, a high titer luciferase (Luc)-expressing pseudovirus packaging system was generated in this paper , which would be readily adapted to SARS-CoV-2 variants for evaluating antibodies.
Posted ContentDOI
A model for pH coupling of the SARS-CoV-2 spike protein open/closed equilibrium.
TL;DR: To investigate possible mediators of pH-dependence, pKa calculations have been made on a set of structures for spike protein ectodomain and fragments from SARS-CoV-2 and other coronaviruses, and it is suggested that histidine residues in S2 and two aspartic acid residues in partially buried salt-bridges contribute to a pH-Dependence of the open/closed equilibrium.
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