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Open AccessJournal ArticleDOI

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.

Leonid Yurkovetskiy, +22 more
- 29 Oct 2020 - 
- Vol. 183, Iss: 3, pp 739
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.
About: 
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.

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Citations
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Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

Siaw Shi Boon, +9 more
- 26 Oct 2021 - 
TL;DR: In this paper, the authors studied the evolution of SARS-CoV-2 S protein over the first 16 months of the pandemic and identified several key amino acid changes that are predicted to confer a substantial impact on transmission and immunological recognition.
Journal ArticleDOI

Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape

Shengyuan Dang, +2 more
- 20 May 2022 - 
TL;DR: The functional mutations in SARS-CoV-2 genomes are summarized to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.
Journal ArticleDOI

Spike Mutation Profiles Associated With SARS-CoV-2 Breakthrough Infections in Delta Emerging and Predominant Time Periods in British Columbia, Canada

Chad D. Fibke, +8 more
- 04 Jul 2022 - 
TL;DR: This profiling method identifies naturally occurring spike mutations associated with BTI, and can be applied to emerging SARS-CoV-2 variants with novel groups of spike mutations.
Journal ArticleDOI

A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands

Carla López-Causapé, +22 more
- 12 Jan 2022 - 
TL;DR: Virus evolution, mainly driven by the acquisition and selection of spike substitutions conferring biological advantages, social restrictions, and size population are apparently key factors for explaining the epidemic patterns registered in the Balearic Islands.
Posted ContentDOI

Safety and immunogenicity of Pfizer/BioNTech SARS-CoV-2 mRNA third booster vaccine against SARS-CoV-2 Omicron variant in Japanese healthcare workers

Yohei Seki, +15 more
- 21 Jan 2022 - 
TL;DR: The third vaccination dose is safe and effective against Omicron infection and the breadth of humoral immunity and cross-reactivity with Omicrons increased, and the cytokine signature and adverse event rate remained unchanged after three dose vaccination.
References
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Chaolin Huang, +28 more
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Na Zhu, +18 more
- 24 Jan 2020 - 
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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