Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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SARS‐CoV‐2 variants and spike mutations involved in second wave of COVID‐19 pandemic in India
R. K. Muttineni,B. R.N.,Kalyani Putty,Kavitha Marapakala,Sandra K.P.,Jaslin Panyam,Aravind Vemula,Shashikant Singh,Subin Balachandran,Viroji Rao S.T.,Anand K. Kondapi +10 more
TL;DR: As SARS‐CoV‐2 variants are emerging rapidly, it is critical to continuously monitor local viral mutations to understand national trends of virus circulation and design better preventive regimens in the country.
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Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2
Hassan Sarker,Rashmi Panigrahi,E. E. Hardy,J. N. Mark Glover,Shokrollah Elahi,Carlos Fernandez-Patron +5 more
TL;DR: Interaction assays indicated that cortisol and dexamethasone separately and cooperatively disrupt S1 interaction with ACE2, through direct binding to S1, without affecting ACE2 catalytic activity.
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Mechanosensing view of SARS-CoV-2 infection by a DNA nano-assembly
TL;DR: In this article , the authors developed a platform in which the virus is anchored with multivalence-controlled aptamers to achieve transfer of the virus-cell mechanical force to a DNA tension gauge tether (Virus-TGT).
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Peptides and peptidomimetics as therapeutic agents for Covid-19
TL;DR: This review is focused on peptides and peptidomimetics as PPI modulators and protease inhibitors against SARS‐CoV‐2.
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Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid Treatment
Matt Spick,A. Campbell,Ivona Baricevic-Jones,Johanna von Gerichten,Holly-May Lewis,Cecile Frampas,Katherine Longman,Alexander J. Stewart,Deborah K. Dunn-Walters,Debra J. Skene,Nophar Geifman,Anthony D. Whetton,Melanie J. Bailey +12 more
TL;DR: It is highlighted that glucocorticoids are not fully effective across the wide range of ‘omics dysregulation caused by COVID-19 infections.
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