Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:Â
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
Citations
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SARS-CoV-2 Viral Variants-Tackling a Moving Target.
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Structural biology of SARS-CoV-2 and implications for therapeutic development.
Haitao Yang,Zihe Rao +1 more
TL;DR: In this paper, structural features of SARS-CoV-2 from the whole viral particle to the individual viral proteins and discuss their functions as well as their potential as targets for therapeutic interventions.
Journal ArticleDOI
Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?
TL;DR: The VOCs characteristics, their mutational patterns, and the role mutations play in immune evasion are summarized in this review.
Journal ArticleDOI
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types.
Zharko Daniloski,Tristan X. Jordan,Juliana K Ilmain,Xinyi Guo,Gira Bhabha,Benjamin R. tenOever,Neville E. Sanjana +6 more
TL;DR: In this article, the authors performed site-directed mutagenesis on wild-type human-codon-optimized Spike to introduce the D614G variant, which is in linkage disequilibrium with an ORF1b protein variant (P314L).
Journal ArticleDOI
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
Richard Copin,Alina Baum,Elzbieta Wloga,Kristen E. Pascal,Stephanie Giordano,Benjamin O. Fulton,Anbo Zhou,Nicole Negron,Kathryn Lanza,Newton Chan,Angel Coppola,Joyce Chiu,Min Ni,Yi Wei,Gurinder S. Atwal,Annabel Romero Hernandez,Kei Saotome,Yi Zhou,Matthew C. Franklin,Andrea T. Hooper,Shane McCarthy,Sara Hamon,Jennifer D. Hamilton,Hilary M. Staples,Kendra J. Alfson,Ricardo Carrion,Shazia Ali,Thomas Norton,Selin Somersan-Karakaya,Sumathi Sivapalasingam,Gary Herman,David M. Weinreich,Leah Lipsich,Neil Stahl,Andrew J. Murphy,George D. Yancopoulos,Christos A. Kyratsous +36 more
TL;DR: In this paper, the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-CoV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations.
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