Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
Citations
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Structural-Dynamics and Binding Analysis of RBD from SARS-CoV-2 Variants of Concern (VOCs) and GRP78 Receptor Revealed Basis for Higher Infectivity
Abbas Khan,Anwar Mohammad,Inamul Haq,Inamul Haq,Mohammad Nasar,Waqar Ahmad,Qudsia Yousafi,Muhammad Suleman,Sajjad Ahmad,Aqel Albutti,Taimoor Khan,Sulaiman K. Marafie,Eman Alshawaf,Syed Shujait Ali,Jehad Abubaker,Dong-Qing Wei +15 more
TL;DR: In this paper, a structural basis for the binding of Glucose-regulated protein 78 (GRP78) to different variants of SARS-CoV-2 using a biomolecular simulation approach was provided.
Journal ArticleDOI
Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants.
TL;DR: In this article , the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody (mAb) therapies was investigated using surface plasmon resonance.
Journal ArticleDOI
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential
Brandon Lam,Yu Jui Kung,John H. Lin,Ssu-Hsueh Tseng,Ya Chea Tsai,Liangmei He,Gianni M Castiglione,Emily R Egbert,Elia J. Duh,Evan M. Bloch,Aaron A.R. Tobian,Aaron M. Milstone,Aaron M. Milstone,Richard B. S. Roden,Tzyy Choou Wu,Chien Fu Hung +15 more
TL;DR: In this paper, the N501Y variant of SARS-CoV-2 allowed respiratory infection in unmodified mice and showed near-complete protection in animals receiving high-antibody-tier plasma.
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Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2
Qiaoli Peng,Runhong Zhou,Nanxing Liu,Hui Wang,Haoran Xu,Meiqing Zhao,Ka-Kit Au,Haode Huang,Li Li,Zhiwei Chen +9 more
TL;DR: In this paper , the entry efficiency of individual spike mutations was determined in vitro using pseudotyped viruses, and the impact of individual mutations on immunogenicity was determined by determining the effect of individual spikes on the infectivity and antigenicity of viruses.
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Pre-Omicron Vaccine Breakthrough Infection Induces Superior Cross-Neutralization against SARS-CoV-2 Omicron BA.1 Compared to Infection Alone
Eveline Santos da Silva,Michel Kohnen,Georges Gilson,Thérèse Staub,Vic Arendt,Christiane Hilger,Jean Servais,Emilie Charpentier,Olivia Domingues,Chantal J. Snoeck,Markus Ollert,Carole Seguin-Devaux,Danielle Perez-Bercoff +12 more
TL;DR: Overall, convalescent sera from patients with moderate disease had higher antibody levels and displayed a higher neutralizing ability against all strains than patients with mild or severe forms of the disease, suggesting a better cross-neutralization and higher affinity of vaccine-elicited antibodies over virus-induced antibodies.
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