Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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The SARS-CoV-2 spike protein: balancing stability and infectivity.
TL;DR: The authors determined a decreased affinity of D614G for ACE2, which appears to be compensated by the presence of many more receptor binding-competent RBDs, which is associated with increased infectivity and viral load in patients with COVID-19.
Journal ArticleDOI
Proteolytic activation of SARS-CoV-2 spike protein.
TL;DR: In this paper, a review of the cleavage activation mechanism of S protein is discussed, with particular focus on the novel coronavirus, severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2).
Journal ArticleDOI
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccines.
TL;DR: In this article, the impact of spike mutated variants of SARS-CoV2 (Alpha, Beta, Gamma, Delta, and Lambda) on the efficacy of subunit recombinant vaccines has been reported.
Journal ArticleDOI
Functional importance of the D614G mutation in the SARS-CoV-2 spike protein.
TL;DR: S(G614), compared to S(D614), mediates more efficient ACE2-mediated transduction of cells by S-pseudotyped vectors and more efficient infection of cells and animals by live SARS-CoV-2.
Journal ArticleDOI
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Anna Winger,Thomas Caspari +1 more
TL;DR: A review of spike mutations can be found in this paper, where the D614G mutation is the hallmark of all variants, as it promotes viral spread by increasing the number of open spike protomers in the homo-trimeric receptor complex.
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