Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TLDR
It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.About:
This article is published in Cell.The article was published on 2020-10-29 and is currently open access. It has received 840 citations till now. The article focuses on the topics: Virion membrane & Protein structure.read more
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Evolution of the SARS-CoV-2 genome and emergence of variants of concern
Iman Safari,Elahe Elahi +1 more
TL;DR: A large-scale whole-genome sequencing of the SARS-CoV-2 genome since its identification in late 2019 has identified many sequence changes and the emergence of novel strains, each described by co-segregation of a particular set of sequence variations as discussed by the authors.
Journal ArticleDOI
Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants.
TL;DR: The emergence of SARS-CoV-2 variants must be examined to allow effective preventive and curative control strategies to be developed as mentioned in this paper, and their effect on vaccines and therapies, and, in particular, monoclonal antibodies (mAbs).
Journal ArticleDOI
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity.
Manojit Bhattacharya,Srijan Chatterjee,Ashish Ranjan Sharma,Govindasamy Agoramoorthy,Chiranjib Chakraborty +4 more
TL;DR: In this article, a review aims to provide several crucial pieces of information associated with the D614 mutational occurrence of SARS-CoV-2 variants and their infectivity patterns.
Posted ContentDOI
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction
Sophie M. C. Gobeil,Katarzyna Janowska,Shana McDowell,Katayoun Mansouri,Robert Parks,Kartik Manne,Victoria Stalls,Megan Kopp,Rory Henderson,Robert J. Edwards,Barton F. Haynes,Priyamvada Acharya +11 more
TL;DR: Cryo-EM structures, antigenicity and proteolysis experiments suggest altered conformational dynamics resulting in enhanced furin cleavage efficiency of the G614 variant, and allosteric effect of changes at the S1/S2 junction on RBD dynamics is revealed.
Journal ArticleDOI
Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants.
TL;DR: In this paper, the authors focused on the current circulating variants of SARS-CoV-2 and the structure-function analysis of key S protein mutations linked with increased affinity, higher infectivity, enhanced transmission rates, and immune escape against this infection.
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