Using EAE to better understand principles of immune function and autoimmune pathology
Manu Rangachari,Vijay K. Kuchroo +1 more
TLDR
A step-by-step elucidation of the network of signals required for T helper 17 (Th17) cell differentiation, as well as the molecular dissection of the Tim-3 negative regulatory signaling pathway in Th1 cells are focused on.About:
This article is published in Journal of Autoimmunity.The article was published on 2013-09-01 and is currently open access. It has received 222 citations till now. The article focuses on the topics: Experimental autoimmune encephalomyelitis & Multiple sclerosis.read more
Citations
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Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
David Schafflick,Chenling Xu,Maike Hartlehnert,Michael Cole,Andreas Schulte-Mecklenbeck,Tobias Lautwein,Jolien Wolbert,Michael Heming,Sven G. Meuth,Tanja Kuhlmann,Catharina C. Gross,Heinz Wiendl,Nir Yosef,Nir Yosef,Gerd Meyer zu Hörste +14 more
TL;DR: A single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis patients is provided, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.
Journal ArticleDOI
Complex regional pain syndrome: A comprehensive and critical review
Andrea T. Borchers,M E Gershwin +1 more
TL;DR: A detailed critical overview of not only the history of CRPS, but also the epidemiology, the clinical features, the pathophysiological studies, the proposed criteria, the therapy and an emphasis that future research should apply more rigorous standards to allow a better understanding ofCRPS are provided.
Journal ArticleDOI
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Shane J. F. Cronin,Shane J. F. Cronin,Shane J. F. Cronin,Corey R. Seehus,Corey R. Seehus,Adelheid Weidinger,Sébastien Talbot,Sébastien Talbot,Sébastien Talbot,Sonja Reissig,Markus Seifert,Yann Pierson,Eileen McNeill,Eileen McNeill,Maria Serena Longhi,Bruna Lenfers Turnes,Taras Kreslavsky,Taras Kreslavsky,Melanie Kogler,David Hoffmann,Melita Ticevic,Débora da Luz Scheffer,Luigi Tortola,Domagoj Cikes,Alexander Jais,Manu Rangachari,Shuan Rao,Magdalena Paolino,Maria Novatchkova,Martin Aichinger,Lee Barrett,Lee Barrett,Alban Latremoliere,Gerald Wirnsberger,Guenther Lametschwandtner,Meinrad Busslinger,Stephen Zicha,Alexandra Latini,Alexandra Latini,Alexandra Latini,Simon C. Robson,Simon C. Robson,Ari Waisman,Nick Andrews,Nick Andrews,Michael Costigan,Keith M. Channon,Keith M. Channon,Guenter Weiss,Andrey V. Kozlov,Mark Joseph Tebbe,Kai Johnsson,Kai Johnsson,Clifford J. Woolf,Clifford J. Woolf,Josef M. Penninger +55 more
TL;DR: The data uncover GCH1, SPR and their downstream metabolite BH4 as critical regulators of T cell biology that can be readily manipulated to either block autoimmunity or enhance anticancer immunity.
Journal ArticleDOI
Vaccines, adjuvants and autoimmunity
TL;DR: There are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection.
Journal ArticleDOI
From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.
Avraham Ben-Nun,Nathali Kaushansky,Naoto Kawakami,Gurumoorthy Krishnamoorthy,Kerstin Berer,Roland S. Liblau,Reinhard Hohlfeld,Hartmut Wekerle +7 more
TL;DR: The contribution of major classic, spontaneous, and humanized EAE models to the understanding of MS pathophysiology and to insights leading to devising current and future therapies for this disease are discussed.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
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Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Jonathan D. Sedgwick,Terrill K. McClanahan,Robert A. Kastelein,Daniel J. Cua +8 more
TL;DR: Using passive transfer studies, it is confirmed that these IL-23–dependent CD4+ T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity.
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