R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
TL;DR: A new technique to measure in vivo tumour tissue fluid transport parameters (hydraulic conductivity and compliance) that influence the systemic and intratumoral delivery of therapeutic agents is developed, helpful in identifying strategies to improve the intrumoral and systemic delivery of gene targeting vectors and other therapeutic agents.
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Continuous Noninvasive Monitoring of pH and Temperature in Rat Walker 256 Carcinoma During Normoglycemia and Hyperglycemia
TL;DR: The extracellular pH and temperature of Walker 256 carcinoma and of normal subcutaneous tissue were measured continuously in unanesthetized female Sprague-Dawley rats for up to 20 hours following glucose or galactose administration and response of large ulcerated tumors was not as uniform.
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Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
TL;DR: Findings show that the induction of cancer cell death before the injection of oncolytic HSV enhances intratumoral virus delivery/penetration and antitumor efficacy.
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Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
TL;DR: It is demonstrated secreted Gluc assay accurately reflects the amount of viable cancer cells in primary and metastatic tumors, and not only tracks metastatic tumor progression but also serves as a longitudinal biomarker for tumor response to treatments.
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Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases
Han-Sin Jeong,Dennis Jones,Shan Liao,Daniel A. Wattson,Cheryl H. Cui,Dan G. Duda,Christopher G. Willett,Rakesh K. Jain,Timothy P. Padera +8 more
TL;DR: Preclinical and clinical evidence is provided that sprouting angiogenesis does not occur during the growth of lymph node metastases, and a new mechanism of treatment resistance to antiangiogenic therapy in adjuvant settings is revealed.