R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal ArticleDOI
Transport of molecules, particles, and cells in solid tumors.
TL;DR: This paradigm of analysis and synthesis has fostered a better understanding of physiological barriers in solid tumors and aided in the development of novel strategies to exploit and/or overcome these barriers for improved cancer detection and treatment.
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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Vikash P. Chauhan,John D. Martin,John D. Martin,Hao Liu,Delphine A. Lacorre,Saloni R. Jain,Saloni R. Jain,Sergey V. Kozin,Triantafyllos Stylianopoulos,Triantafyllos Stylianopoulos,Ahmed S. Mousa,Xiaoxing Han,Pichet Adstamongkonkul,Zoran B. Popović,Peigen Huang,Moungi G. Bawendi,Yves Boucher,Rakesh K. Jain +17 more
TL;DR: Losartan reduces solid stress in tumours resulting in increased vascular perfusion, thereby potentiating chemotherapy and reducing hypoxia in breast and pancreatic cancer models, suggesting that angiotensin inhibitors —inexpensive drugs with decades of safe use — could be rapidly repurposed as cancer therapeutics.
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Tissue engineering: creation of long-lasting blood vessels.
Naoto Koike,Dai Fukumura,Oliver Gralla,Patrick Au,Jeffrey S. Schechner,Rakesh K. Jain,Rakesh K. Jain +6 more
TL;DR: It is shown that a network of long-lasting blood vessels can be formed in mice by co-implantation of vascular endothelial cells and mesenchymal precursor cells, by-passing the need for risky genetic manipulations.
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Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood
Yong S. Chang,Emmanuelle di Tomaso,Donald M. McDonald,Rosemary Jones,Rakesh K. Jain,Lance L. Munn +5 more
TL;DR: The data offer a possible explanation for the antivascular effects of cytotoxic agents and suggest potential strategies for targeting the tumor vasculature.
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Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
Dai Fukumura,Rakesh K. Jain +1 more
TL;DR: Anti-angiogenic treatments directly targeting angiogenic signaling pathways as well as indirectly modulating angiogenesis show normalization of tumor vasculature and microenvironment at least transiently in both preclinical and clinical settings.