R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Book ChapterDOI
Mass transport in tumors: characterization and applications to chemotherapy.
TL;DR: This chapter provides a unified framework for the characterization of convection, diffusion, binding, and metabolism of chemotherapeutic agents in tumors and normal tissues and adequate for predicting drug distributions in normal and neoplastic tissues.
Journal ArticleDOI
Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma: The GEMCAD 1402 Randomized Clinical Trial.
Carlos Fernández-Martos,Carles Pericay,Ferran Losa,Rocio Garcia-Carbonero,Laura Layos,Nuria Rodríguez-Salas,Marta Martin-Richard,Vicente Alonso-Orduña,R. Vera,Javier Gallego,Jaume Capdevila,Antonieta Salud,Miquel Nogué,Joan Maurel,Inmaculada Guash,Clara Montagut,Carlos F. Lopez,Ismael Macias,Rakesh K. Jain,Xabier García-Albéniz +19 more
TL;DR: The findings suggest that adding aflibercept to an induction regimen using mFOLFOX6 plays a role in increasing the pCR rate in patients with high-risk rectal adenocarcinoma, without substantially increasing surgical complications.
Journal ArticleDOI
α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents
Rakesh K. Jain,A. Sundram,Sara Lopez,G. Neckermann,Charlotte Wu,C. Hackbarth,Dawn Chen,Wen Wang,Neil S. Ryder,Beat Weidmann,Dinesh V. Patel,Joaquim Trias,Richard C. White,Zhengyu Yuan +13 more
TL;DR: This study explores the structure-activity relationship of various chelator groups, alpha substituent, P(2)' and P(3)' substituents in order to achieve optimal antibacterial activity with minimal toxicity liability.
Journal ArticleDOI
Branching of the p-nitrophenol (PNP) degradation pathway in burkholderia sp. Strain SJ98: Evidences from genetic characterization of PNP gene cluster
Surendra Vikram,Janmejay Pandey,Janmejay Pandey,Nidhi Bhalla,Gunjan Pandey,Gunjan Pandey,Anuradha Ghosh,Anuradha Ghosh,Fazlurrahman Khan,Rakesh K. Jain,Gajendra P. S. Raghava +10 more
TL;DR: It is proposed that strain SJ98 presents a useful model system for future studies on evolution of microbial degradation of PNP because of involvement of both ‘HQ’ and ‘BT’ ring cleavage pathways in PNP degradation by Burkholderia sp.