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Rakesh K. Jain

Researcher at Harvard University

Publications -  1528
Citations -  198912

Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.

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Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity

John D. Martin, +4 more
- 01 Dec 2016 - 
TL;DR: Two strategies to reengineer the tumor microenvironment-vessel normalization and decompression-that can alleviate hypoxia are summarized and discussed, and how these two strategies alone and in combination with each other-or other therapeutic strategies-may overcome the challenges posed by cancer heterogeneity are discussed.
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In vivo imaging of tumors.

Edward B. Brown, +3 more
- 01 Jul 2010 - 
TL;DR: These preparations allow an implanted tumor to grow for several weeks in an optically accessible location in vivo, making it possible to examine the living tumor with high-resolution light microscopy in a repetitive manner.
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A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles

Sai T. Reddy, +3 more
- 01 Oct 2006 - 
TL;DR: An in vivo model for evaluating interstitial convection of injected macromolecules and nanoparticles is developed, testifying to sensitivity and usefulness of the model in comparing solutes of different size, shape, and charge.
Journal Article

Interstitial Transport of Rabbit and Sheep Antibodies in Normal and Neoplastic Tissues

Michelle A. Clauss, +1 more
- 15 Jun 1990 - 
TL;DR: The molecular weight dependence of Deff provides a rational basis for the use of bifunctional antibodies and antibody-enzyme conjugates to increase the delivery of low molecular weight anticancer agents to solid tumors.
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Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.

Yong S. Chang, +8 more
- 01 Mar 2000 - 
TL;DR: It is indicated that VEGF affects endothelial transport properties differently depending on the vessel type and that differences in cell signaling pathways underlie the differences in V EGF responsiveness.