R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal ArticleDOI
Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis: correction
Peter Carmeliet,Yuval Dor,Jean-Marc Herbert,Dai Fukumura,Koen Brusselmans,Mieke Dewerchin,Michal Neeman,Françoise Bono,Rinat Abramovitch,Patrick H. Maxwell,Cameron J. Koch,Peter J. Ratcliffe,Lieve Moons,Rakesh K. Jain,Desire Collen,Eli Keshert +15 more
TL;DR: This corrects the article DOI: 10.1038/28867 to indicate that the author of the paper is a doctor, not a scientist, and the paper was originally published in the British Journal of Sports Medicine.
Journal ArticleDOI
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Timothy P. Padera,Angera H. Kuo,Tohru Hoshida,Shan Liao,Jennifer Lobo,Kevin R. Kozak,Dai Fukumura,Rakesh K. Jain +7 more
TL;DR: Data indicate that the response of lymphatic vessels to a TKI can determine the incidence of lymphatics metastasis, independent of the effect of the TKI on blood vessels.
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Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis
Giorgio Seano,Giorgio Seano,Giulia Chiaverina,Paolo Armando Gagliardi,Laura di Blasio,Alberto Puliafito,Claire Bouvard,Claire Bouvard,Roberto Sessa,Roberto Sessa,Guido Tarone,Lydia Sorokin,Dominique Helley,Rakesh K. Jain,Guido Serini,Federico Bussolino,Luca Primo +16 more
TL;DR: It is shown that the angiogenic endothelium is characterized by the presence of functional podosome rosettes, which are precursors of de novo branching points and represent a key feature in the formation of new blood vessels.
Journal Article
Local Imbalance of Proangiogenic and Antiangiogenic Factors: A Potential Mechanism of Focal Necrosis and Dormancy in Tumors
TL;DR: A mathematical framework that describes production, diffusion, and degradation of factors in tumor and host tissue and their effect on angiogenesis at local and distal sites is presented and suggests generally that diffusible factors produced by tumors can stimulate responses in adjacent host tissue, preparing it for further tumor invasion.