R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal ArticleDOI
Tumor Induction of VEGF Promoter Activity in Stromal Cells
Dai Fukumura,Ramnik J. Xavier,Takeyuki Sugiura,Yi Chen,Eun Chung Park,Naifang Lu,Martin K. Selig,Gunnlaugur P. Nielsen,Tatyana Taksir,Rakesh K. Jain,Brian Seed +10 more
TL;DR: The finding that the VEGF promoter of nontransformed cells is strongly activated by the tumor microenvironment points to a need to analyze and understand stromal cell collaboration in tumor angiogenesis.
Journal Article
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Fan Yuan,Michael Leunig,Shi Kun Huang,David A. Berk,Demetrios Papahadjopoulos,Rakesh K. Jain +5 more
TL;DR: Microvascular permeability and interstitial penetration of sterically stabilized liposomes in both normal s.c. tissue and human colon adenocarcinoma LS174T xenograft were quantified to provide new insights into the mechanisms of transendothelial pathways ofliposomes and improvements in liposome-mediated drug delivery.
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Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
Dai Fukumura,Takeshi Gohongi,Ananth Kadambi,Yotaro Izumi,Jennifer Ang,Chae-Ok Yun,Donald G. Buerk,Paul L. Huang,Rakesh K. Jain +8 more
TL;DR: It is suggested that eNOS plays a predominant role in VEGF-induced angiogenesis and vascular permeability in vivo, and selective modulation of eN OS activity is a promising strategy for altering angiogenic and vascular porousness in vivo.
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Multistage nanoparticle delivery system for deep penetration into tumor tissue
Cliff Wong,Triantafyllos Stylianopoulos,Jian Cui,John D. Martin,Vikash P. Chauhan,Wen Jiang,Zoran B. Popović,Rakesh K. Jain,Moungi G. Bawendi,Dai Fukumura +9 more
TL;DR: In vivo circulationHalf-life and intratumoral diffusion measurements indicate that the multistage nanoparticles exhibited both the long circulation half-life necessary for the EPR effect and the deep tumor penetration required for delivery into the tumor's dense collagen matrix.
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Lymphatic metastasis in the absence of functional intratumor lymphatics.
Timothy P. Padera,Ananth Kadambi,Emmanuelle di Tomaso,Carla Mouta Carreira,Edward B. Brown,Yves Boucher,Noah C. Choi,Douglas J. Mathisen,John C. Wain,Eugene J. Mark,Lance L. Munn,Rakesh K. Jain +11 more
TL;DR: Functional lymphatics associated with mouse tumors expressing normal or elevated levels of vascular endothelial growth factor–C (VEGF-C) are examined to suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically.