R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight
TL;DR: In this article, a physiologically based mathematical model was developed to simulate the regulatory effects of the leptin pathway on murine energy homeostasis and revealed the possibility of multiple steady states for body weight.
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Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold
Christopher M. Lemon,Peter N. Curtin,Rebecca C. Somers,Andrew B. Greytak,Andrew B. Greytak,Ryan M. Lanning,Rakesh K. Jain,Moungi G. Bawendi,Daniel G. Nocera +8 more
TL;DR: In this article, a quantum dot and an analyte-responsive dye are used to measure pH, oxygen, and glucose in the tumor microenvironment by using multiphoton imaging.
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Temperature Distributions in Normal and Neoplastic Tissues during Normothermia and Hyperthermia
TL;DR: Simple mathematical models that can be used to predict temperature distributions in the normal and neoplastic tissues of various mammals during normothermia and hyperthermia are presented to improve tumor detection by thermography and in designing heating protocols for hyperthermic treatments.
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A Phase II and Biomarker Study of Sorafenib Combined with Modified FOLFOX in Patients with Advanced Hepatocellular Carcinoma.
Lipika Goyal,Hui Zheng,Thomas A. Abrams,Rebecca A. Miksad,Rebecca A. Miksad,Andrea J. Bullock,Andrea J. Bullock,Jill N. Allen,Matthew B. Yurgelun,Jeffrey W. Clark,Avinash Kambadakone,Alona Muzikansky,Michelle Knowles,Aralee Galway,Anthony James Afflitto,Caroline Dinicola,Eileen Regan,Tai Hato,Emilie Mamessier,Kohei Shigeta,Rakesh K. Jain,Dan G. Duda,Andrew X. Zhu +22 more
TL;DR: Sorafenib + mFOLFOX met the prespecified endpoint with encouraging efficacy but moderate hepatotoxicity and may be effective in select patients with adequate liver reserve, and biomarker evaluations suggested a correlation between time-to-progression (TTP) and angiogenic biomarkers and circulating Tregs.
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Differential Transplantability of Tumor-Associated Stromal Cells
Dan G. Duda,Dai Fukumura,Lance L. Munn,Michael F. Booth,Edward B. Brown,Peigen Huang,Brian Seed,Rakesh K. Jain +7 more
TL;DR: It is reported that angiogenic stroma associated with tumor or adipose tissue persists when transplanted, remains functional, and governs the initial neovascularization of grafted tissue fragments for more than 4 weeks after implantation.