R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal Article
Tumor Necrosis Factor α-induced Leukocyte Adhesion in Normal and Tumor Vessels: Effect of Tumor Type, Transplantation Site, and Host Strain
TL;DR: Investigation of the extent to which the host leukocytes roll and adhere to vessels of different tumors suggests that basal leukocyte rolling is lower in tumor vessels than in normal vessels and that the TNF-alpha response is dependent on tumor type, transplantation site, and host strain.
Journal Article
Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Eric Neil Kaufman,Rakesh K. Jain +1 more
TL;DR: It is concluded that bivalent equilibrium binding constants are useful only in antibody screening, where experimental conditions are identical for all series and must be used with caution in predicting in vivo antibody distribution.
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Intratumoral Lymphatic Vessels: A Case of Mistaken Identity or Malfunction?
Rakesh K. Jain,Brenda T. Fenton +1 more
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Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Joao Incio,Jennifer A. Ligibel,Daniel McManus,Priya Suboj,Priya Suboj,Keehoon Jung,Kosuke Kawaguchi,Matthias Pinter,Matthias Pinter,Suboj Babykutty,Suboj Babykutty,Shan M. Chin,Trupti Vardam,Yuhui Huang,Nuh N. Rahbari,Sylvie Roberge,Dannie Wang,Igor L. Gomes-Santos,Igor L. Gomes-Santos,Stefan Puchner,Christopher L. Schlett,Udo Hoffmman,Marek Ancukiewicz,Sara M. Tolaney,Ian E. Krop,Dan G. Duda,Yves Boucher,Dai Fukumura,Rakesh K. Jain +28 more
TL;DR: The authors target these pathways in mouse models of cancer with and without obesity and demonstrate that the deleterious effects of obesity on VEGF inhibition can be overcome through the appropriate combination therapy.
Journal ArticleDOI
Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory
TL;DR: A novel integrative method for characterizing transport in the lymphatic capillaries in the tail of the anesthetized mouse is presented, which is both sensitive and reproducible for quantifying uptake and flow and can be used to examine various aspects of transport physiology of the initial lymphatics.