R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
Triantafyllos Stylianopoulos,John D. Martin,John D. Martin,Vikash P. Chauhan,Saloni R. Jain,Saloni R. Jain,Benjamin Diop-Frimpong,Benjamin Diop-Frimpong,Nabeel Bardeesy,Barbara L. Smith,Cristina R. Ferrone,Francis J. Hornicek,Yves Boucher,Lance L. Munn,Rakesh K. Jain +14 more
TL;DR: This work shows that therapeutic depletion of carcinoma-associated fibroblasts with an inhibitor of the sonic hedgehog pathway reduces solid stress, decompresses blood and lymphatic vessels, and increases perfusion, and can serve as a rapid screen for stress-reducing and perfusion-enhancing drugs.
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Dissecting tumour pathophysiology using intravital microscopy
TL;DR: Intravital microscopy has provided unprecedented molecular, cellular, anatomical and functional insights into these barriers and has revealed new approaches to improved detection and treatment in tumours.
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Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Alain Pluen,Yves Boucher,Saroja Ramanujan,Trevor D. McKee,Takeshi Gohongi,Emmanuelle di Tomaso,Edward B. Brown,Yotaro Izumi,Robert B. Campbell,David A. Berk,Rakesh K. Jain +10 more
TL;DR: The results point to the necessity of developing site-specific drug carriers to improve the delivery of molecular medicine to solid tumors.
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Microvascular permeability of normal and neoplastic tissues.
TL;DR: These results on increased permeability and increased diffusivity in tumors provide a rational basis for the use of large-molecular-weight agents in the detection and treatment of solid tumors.