R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
Papers
More filters
Journal Article
Understanding barriers to drug delivery: high resolution in vivo imaging is key.
TL;DR: In this issue of Clinical Cancer Research, Lankelma et al. report on doxorubicin gradients in biopsies of breast tumors from patients, finding the gradients are pronounced 2 h after i.v. injection and become negligible 24 h later.
Journal ArticleDOI
A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma.
Theodore S. Hong,David P. Ryan,Darrell R. Borger,Lawrence S. Blaszkowsky,Beow Y. Yeap,Marek Ancukiewicz,Vikram Deshpande,Shweta Shinagare,Jennifer Y. Wo,Yves Boucher,Raymond C. Wadlow,Eunice L. Kwak,Jill N. Allen,Jeffrey W. Clark,Andrew X. Zhu,Cristina R. Ferrone,Harvey J. Mamon,Judith Adams,Barbara Winrich,Tarin Grillo,Rakesh K. Jain,Thomas F. DeLaney,Carlos Fernandez-del Castillo,Dan G. Duda +23 more
TL;DR: This study met the primary endpoint by showing a rate of 4.1% grade 3 toxicity for neoadjuvant short-course proton-based chemoradiation, and KRAS(G12D) status and high CXCR7 expression and circulating CEA, CA19-9, and HGF levels were associated with poor survival.
Journal ArticleDOI
Mice Lacking E-Selection Show Normal Numbers of Rolling Leukocytes but Reduced Leukocyte Stable Arrest on Cytokine-Activated Microvascular Endothelium
David S. Milstone,David S. Milstone,Dai Fukumura,Richard C. Padgett,Richard C. Padgett,Peter E. O'Donnell,Vannessa M. Davis,Oscar J. Benavidez,Wayne L. Monsky,Robert J. Melder,Rakesh K. Jain,Michael A. Gimbrone +11 more
TL;DR: The role of E‐selectin in blood leukocyte interactions with microvascular endothelium in vivo is examined and it is shown that E‐ selectin mediates transient interactions between leukocytes and cytokine‐activated endothelia in vitro.
Journal ArticleDOI
Extravascular transport in normal and tumor tissues
TL;DR: Various types of experimental tumor models which have been used in animals to represent human tumors are discussed and mathematical models of extravascular transport are discussed from the prespective of two approaches: compartmental and distributed.
Journal ArticleDOI
Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression
Andrew F. Leuchter,Ian A. Cook,David Feifel,John W. Goethe,Mustafa M. Husain,Linda L. Carpenter,Michael E. Thase,Andrew D. Krystal,Noah S. Philip,Mahendra T. Bhati,William J. Burke,Robert H Howland,Yvette I. Sheline,Scott Aaronson,Dan V. Iosifescu,John P. O'Reardon,William S. Gilmer,Rakesh K. Jain,Karl Burgoyne,Bill Phillips,Paul J. Manberg,Joseph M. Massaro,Aimee M. Hunter,Sarah H. Lisanby,Mark S. George +24 more
TL;DR: Results suggest that sTMS may be effective, safe, and well tolerated for treating MDD when administered as intended.