R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal ArticleDOI
Fatty acid synthesis is required for breast cancer brain metastasis.
Gino B. Ferraro,Ahmed Ali,Alba Luengo,David P. Kodack,David P. Kodack,Amy Deik,Keene L. Abbott,Divya Bezwada,Landry Blanc,Landry Blanc,Brendan Prideaux,Brendan Prideaux,Xin Jin,Jessica M. Possada,Jiang Chen,Christopher R. Chin,Zohreh Amoozgar,Raphael Ferreira,Raphael Ferreira,Ivy X. Chen,Kamila Naxerova,Christopher W. Ng,Anna M. Westermark,Mark Duquette,Sylvie Roberge,Neal I. Lindeman,Costas A. Lyssiotis,Costas A. Lyssiotis,Jens Nielsen,David E. Housman,Dan G. Duda,Elena F. Brachtel,Todd R. Golub,Lewis C. Cantley,Lewis C. Cantley,John M. Asara,Shawn M. Davidson,Shawn M. Davidson,Dai Fukumura,Véronique Dartois,Clary B. Clish,Rakesh K. Jain,Matthew G. Vander Heiden,Matthew G. Vander Heiden +43 more
TL;DR: It is determined that genetic or pharmacological inhibition of fatty acid synthase (FASN) reduces HER2+ breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.
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Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma.
Lakshmi Nayak,Annette M. Molinaro,Katherine B. Peters,Jennifer Clarke,Justin T. Jordan,John de Groot,Leia Nghiemphu,Thomas Kaley,Howard Colman,Christine McCluskey,Sarah C. Gaffey,Timothy R. Smith,David J. Cote,Mariano Severgnini,Jennifer H. Yearley,Qing Zhao,Wendy M. Blumenschein,Dan G. Duda,Alona Muzikansky,Rakesh K. Jain,Patrick Y. Wen,David A. Reardon +21 more
TL;DR: Pembrolizumab was ineffective as monotherapy and with bevacIZumab for recurrent glioblastoma, and baseline dexamethasone use and tumor MGMT warrant further study as potential biomarkers in gliOBlastoma immunotherapy trials.
Journal ArticleDOI
Migration enhanced lateral epitaxial overgrowth of AlN and AlGaN for high reliability deep ultraviolet light emitting diodes
Rakesh K. Jain,Wenhong Sun,J. W. Yang,Maxim S. Shatalov,Xiaobo Sharon Hu,A. Sattu,A. Lunev,J. Deng,I. Shturm,Yuriy Bilenko,R. Gaska,Michael Shur +11 more
TL;DR: In this paper, the authors report on the growth of low-defect thick films of AlN and AlGaN on trenched AlGAN/sapphire templates using migration enhanced lateral epitaxial overgrowth.
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Photocatalytic degradation of 2-chlorophenol: a study of kinetics, intermediates and biodegradability.
TL;DR: The biochemical oxygen demand (BOD) of treated 2-CP solutions improved substantially and a tentative mechanistic pathway to explain formation of higher carbon intermediates is presented.
Journal ArticleDOI
Too Fit To Fracture: outcomes of a Delphi consensus process on physical activity and exercise recommendations for adults with osteoporosis with or without vertebral fractures
Lora Giangregorio,Lora Giangregorio,Stuart M. McGill,John D. Wark,Judi Laprade,Ari Heinonen,Maureen C. Ashe,Norma J. MacIntyre,Angela M. Cheung,Kathy M. Shipp,Heather H. Keller,Rakesh K. Jain,Alexandra Papaioannou +12 more
TL;DR: Recommendations guide health care providers on assessment, exercise prescription, and safe movement for individuals with osteoporosis and examples of spine-sparing techniques and exercise prescription elements are provided.