R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Diffusion of Macromolecules in Agarose Gels: Comparison of Linear and Globular Configurations
TL;DR: Not only did flexible macromolecules exhibit greater mobility in the gel than did comparable-size rigid spherical particles, they also proved to be a more useful probe of available space between fibers.
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Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
Dai Fukumura,Rakesh K. Jain +1 more
TL;DR: A judicious application of anti‐angiogenic therapy has the potential to overcome problems by normalizing the tumor vessels and making them more efficient for delivery of oxygen and drugs.
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Biomarkers of response and resistance to antiangiogenic therapy.
Rakesh K. Jain,Dan G. Duda,Christopher G. Willett,Dushyant V. Sahani,Andrew X. Zhu,Jay S. Loeffler,Tracy T. Batchelor,A. Gregory Sorensen +7 more
TL;DR: The current challenges in establishing biomarkers of antiangiogenic therapy are discussed, a number of potential systemic, circulating, tissue and imaging biomarkers have emerged from recently completed phase I–III studies, and all of them need to be validated prospectively.
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Bone marrow derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature
TL;DR: Human bone marrow-derived mesenchymal stem cells (hMSCs) are perivascular cell precursors and may serve as an attractive source of cells for use in vascular tissue engineering and for the study of periv vascular cell differentiation.
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Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
TL;DR: This review discusses the origins and implications of transport barriers to drug delivery in tumors, and highlights strategies for overcoming these barriers by modulating either drug properties or the tumor microenvironment itself to enhance the delivery and effectiveness of drugs in tumors.