R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
Melodi Javid Whitley,Diana M. Cardona,Alexander L. Lazarides,Ivan Spasojevic,Jorge Ferrer,Joan Cahill,Chang-Lung Lee,Matija Snuderl,Dan G. Blazer,E. Shelley Hwang,Rachel A. Greenup,Paul J. Mosca,Jeffrey K. Mito,Kyle C. Cuneo,Nicole A. Larrier,Erin K. O'Reilly,Richard F. Riedel,William C. Eward,David B. Strasfeld,Dai Fukumura,Rakesh K. Jain,W. David Lee,Linda G. Griffith,Moungi G. Bawendi,David G. Kirsch,Brian E. Brigman +25 more
TL;DR: In this paper, a protease-activated fluorescent imaging probe, LUM015, was used to detect cancer in vivo in a mouse model of soft tissue sarcoma (STS) and ex vivo in the first-in-human phase 1 clinical trial.
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Fractal Characteristics of Tumor Vascular Architecture During Tumor Growth and Regression
TL;DR: Tumor vascular networks are different from normal vascular networks, but the mechanisms underlying these differences are not known, and understanding these mechanisms may be the key to improving the efficacy of treatment of solid tumors.
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Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice
TL;DR: The vascular permeability of Texas Red-labeled bovine serum albumin in human tumor xenograft LS174T implanted in dorsal skin-fold chamber in severe combined immunodeficient mice was measured using this method.
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Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma
Kohei Shigeta,Kohei Shigeta,Meenal Datta,Tai Hato,Tai Hato,Shuji Kitahara,Ivy X. Chen,Aya Matsui,Hiroto Kikuchi,Emilie Mamessier,Shuichi Aoki,Shuichi Aoki,Rakesh R. Ramjiawan,Rakesh R. Ramjiawan,Hiroki Ochiai,Nabeel Bardeesy,Peigen Huang,Mark Cobbold,Andrew X. Zhu,Rakesh K. Jain,Dan G. Duda +20 more
TL;DR: Combining PD‐1 blockade with antiangiogenesis has shown promise in substantially increasing the fraction of patients with HCC who respond to treatment, but the mechanism of this interaction is unknown.
Journal ArticleDOI
Role of nitric oxide in angiogenesis and microcirculation in tumors.
Dai Fukumura,Rakesh K. Jain +1 more
TL;DR: Modulation of NO level in tumor vessels can alter tumor hemodynamics and thus augment oxygen, drug, gene vector and effector cell delivery to solid tumors.