Rakesh K. Jain

TL;DR: This work used the nucleoside analogue bromodeoxyuridine (BrdUrd) in combination with five-color flow cytometric analysis to evaluate T lymphocyte turnover rates in normal and simian immunodeficiency virus (SIV)-infected rhesus macaques, providing direct evidence for increased rates of both CD4(+) and CD8(+) T cell turnover in AIDS virus infection.

TL;DR: 5 mg vortioxetine did not differ significantly from placebo in reducing depression symptoms after 6 wk of treatment in adults with MDD in an out-patient setting.

TL;DR: The alleviation of desmoplasia by metformin was associated with a reduction in ECM remodeling, epithelial-to-mesenchymal transition (EMT) and ultimately systemic metastasis in overweight diabetic PDAC patients.

TL;DR: Model simulations of various antiangiogenic strategies show that those therapies that effectively target both endothelial and endothelial progenitor cells, either by restoring the balance between angiogenic stimulators and inhibitors or by targeting both types of cells directly, are most effective at delaying tumor growth.

TL;DR: The imaging biomarker studies indicate that bevacizumab-based treatment—while reducing blood flow, volume, and permeability in the overall population—may be associated with improved survival in patients with improved tumor vasculature and blood perfusion after treatment.